Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin

Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and compariso...

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Autores principales: Lavoie, Serge, Gauthier, Charles, Legault, Jean, Mercier, Sylvain, Mshvildadze, Vakhtang, Pichette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740800/
https://www.ncbi.nlm.nih.gov/pubmed/23946828
http://dx.doi.org/10.3762/bjoc.9.150
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author Lavoie, Serge
Gauthier, Charles
Legault, Jean
Mercier, Sylvain
Mshvildadze, Vakhtang
Pichette, André
author_facet Lavoie, Serge
Gauthier, Charles
Legault, Jean
Mercier, Sylvain
Mshvildadze, Vakhtang
Pichette, André
author_sort Lavoie, Serge
collection PubMed
description Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC(50) = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).
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spelling pubmed-37408002013-08-14 Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin Lavoie, Serge Gauthier, Charles Legault, Jean Mercier, Sylvain Mshvildadze, Vakhtang Pichette, André Beilstein J Org Chem Full Research Paper Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC(50) = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM). Beilstein-Institut 2013-07-04 /pmc/articles/PMC3740800/ /pubmed/23946828 http://dx.doi.org/10.3762/bjoc.9.150 Text en Copyright © 2013, Lavoie et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Lavoie, Serge
Gauthier, Charles
Legault, Jean
Mercier, Sylvain
Mshvildadze, Vakhtang
Pichette, André
Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title_full Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title_fullStr Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title_full_unstemmed Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title_short Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin
title_sort lanostane- and cycloartane-type triterpenoids from abies balsamea oleoresin
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740800/
https://www.ncbi.nlm.nih.gov/pubmed/23946828
http://dx.doi.org/10.3762/bjoc.9.150
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