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Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

RATIONALE: TGF-β, a mediator of pulmonary fibrosis, is a genetic modifier of CF respiratory deterioration. The mechanistic relationship between TGF-β signaling and CF lung disease has not been determined. OBJECTIVE: To investigate myofibroblast differentiation in CF lung tissue as a novel pathway by...

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Detalles Bibliográficos
Autores principales:	Harris, William T., Kelly, David R., Zhou, Yong, Wang, Dezhi, Macewen, Mark, Hagood, James S., Clancy, J. P., Ambalavanan, Namasivayam, Sorscher, Eric J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741283/ https://www.ncbi.nlm.nih.gov/pubmed/23950911 http://dx.doi.org/10.1371/journal.pone.0070196

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