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Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells
In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741302/ https://www.ncbi.nlm.nih.gov/pubmed/23950961 http://dx.doi.org/10.1371/journal.pone.0070553 |
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author | Povysheva, Nadezhda V. Zaitsev, Aleksey V. Gonzalez-Burgos, Guillermo Lewis, David A. |
author_facet | Povysheva, Nadezhda V. Zaitsev, Aleksey V. Gonzalez-Burgos, Guillermo Lewis, David A. |
author_sort | Povysheva, Nadezhda V. |
collection | PubMed |
description | In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same “fast-spiking” phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species. |
format | Online Article Text |
id | pubmed-3741302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37413022013-08-15 Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells Povysheva, Nadezhda V. Zaitsev, Aleksey V. Gonzalez-Burgos, Guillermo Lewis, David A. PLoS One Research Article In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same “fast-spiking” phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species. Public Library of Science 2013-08-12 /pmc/articles/PMC3741302/ /pubmed/23950961 http://dx.doi.org/10.1371/journal.pone.0070553 Text en © 2013 Povysheva et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Povysheva, Nadezhda V. Zaitsev, Aleksey V. Gonzalez-Burgos, Guillermo Lewis, David A. Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title | Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title_full | Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title_fullStr | Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title_full_unstemmed | Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title_short | Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells |
title_sort | electrophysiological heterogeneity of fast-spiking interneurons: chandelier versus basket cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741302/ https://www.ncbi.nlm.nih.gov/pubmed/23950961 http://dx.doi.org/10.1371/journal.pone.0070553 |
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