Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair

Reduced sensitivity of prostate cancer (PC) cells to radiation therapy poses a significant challenge in the clinic. Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth factor receptor (IGF1R), and crosstalk between these two signaling pathways have been implicated in th...

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Detalles Bibliográficos
Autores principales: Wang, Yong, Yuan, Jian Lin, Zhang, Yun Tao, Ma, Jian Jun, Xu, Peng, Shi, Chang Hong, Zhang, Wei, Li, Yu Mei, Fu, Qiang, Zhu, Guang Feng, Xue, Wei, Lei, Yong Hua, Gao, Jing Yu, Wang, Juan Ying, Shao, Chen, Yi, Cheng Gang, Wang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741308/
https://www.ncbi.nlm.nih.gov/pubmed/23950876
http://dx.doi.org/10.1371/journal.pone.0068784

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