Cargando…

Autophagy Inhibition with Monensin Enhances Cell Cycle Arrest and Apoptosis Induced by mTOR or Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cells

BACKGROUND: In cancer cells, autophagy is generally induced as a pro-survival mechanism in response to treatment-associated genotoxic and metabolic stress. Thus, concurrent autophagy inhibition can be expected to have a synergistic effect with chemotherapy on cancer cell death. Monensin, a polyether...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Hyeong Sim, Jeong, Eun-Hui, Lee, Tae-Gul, Kim, Seo Yun, Kim, Hye-Ryoun, Kim, Cheol Hyeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Academy of Tuberculosis and Respiratory Diseases 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741474/ https://www.ncbi.nlm.nih.gov/pubmed/23946753 http://dx.doi.org/10.4046/trd.2013.75.1.9

Ejemplares similares

Dual Inhibition of PI3K/Akt/mTOR Pathway and Role of Autophagy in Non-Small Cell Lung Cancer Cells
por: Jeong, Eun-Hui, et al.
Publicado: (2012)

Fhit, a tumor suppressor protein, induces autophagy via 14-3-3τ in non-small cell lung cancer cells
por: Lee, Tae-Gul, et al.
Publicado: (2017)

Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway
por: Lee, Ho Jeong, et al.
Publicado: (2018)

Altered expression of cellular proliferation, apoptosis and the cell cycle-related genes in lung cancer cells with acquired resistance to EGFR tyrosine kinase inhibitors
por: Lee, Tae-Gul, et al.
Publicado: (2017)

Association between thyroid cancer and epidermal growth factor receptor mutation in female with nonsmall cell lung cancer
por: Kim, Seo Yun, et al.
Publicado: (2017)

mTOR, autophagy, and reprogramming
por: Tang, Bor Luen
Publicado: (2014)

Gartanin induces cell cycle arrest and autophagy and suppresses migration involving PI3K/Akt/mTOR and MAPK signalling pathway in human glioma cells
por: Luo, Ming, et al.
Publicado: (2016)

mTOR Pathways in Cancer and Autophagy
por: Paquette, Mathieu, et al.
Publicado: (2018)

Harmine Hydrochloride Triggers G2/M Cell Cycle Arrest and Apoptosis in HCT116 Cells through ERK and PI3K/AKT/mTOR Signaling Pathways
por: Kim, Gi Dae
Publicado: (2021)

Plumbagin induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer cells
por: Wang, Feng, et al.
Publicado: (2015)

Benzoxazole Derivative K313 Induces Cell Cycle Arrest, Apoptosis and Autophagy Blockage and Suppresses mTOR/p70S6K Pathway in Nalm-6 and Daudi Cells
por: Zhong, Wenying, et al.
Publicado: (2020)

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
por: Blagosklonny, Mikhail V.
Publicado: (2012)

mTOR favors senescence over quiescence in p53-arrested cells
por: Schug, Thaddeus T.
Publicado: (2010)

The mTOR–Autophagy Axis and the Control of Metabolism
por: Deleyto-Seldas, Nerea, et al.
Publicado: (2021)

mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
por: Cayo, Angel, et al.
Publicado: (2021)

Amorphigenin from Amorpha fruticosa L. Root Extract Induces Autophagy-Mediated Melanosome Degradation in mTOR-Independent- and AMPK-Dependent Manner
por: Lee, Ki Won, et al.
Publicado: (2022)

Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells
por: Zi, Dan, et al.
Publicado: (2015)

Concurrent Autophagy Inhibition Overcomes the Resistance of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Human Bladder Cancer Cells
por: Kang, Minyong, et al.
Publicado: (2017)

Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways
por: Ock, Chae Won, et al.
Publicado: (2021)

Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways
por: Ock, Chae Won, et al.
Publicado: (2021)

Sanggenol L Induces Apoptosis and Cell Cycle Arrest via Activation of p53 and Suppression of PI3K/Akt/mTOR Signaling in Human Prostate Cancer Cells
por: Won, Yeong-Seon, et al.
Publicado: (2020)

4-Hydroxyderricin Promotes Apoptosis and Cell Cycle Arrest through Regulating PI3K/AKT/mTOR Pathway in Hepatocellular Cells
por: Gao, Xiang, et al.
Publicado: (2021)

Geranium thunbergii extract-induced G1 phase cell cycle arrest and apoptosis in gastric cancer cells
por: Lee, Hana, et al.
Publicado: (2019)

Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma
por: Xie, Xiaoqi, et al.
Publicado: (2013)

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline
por: Lin, Shao Jian, et al.
Publicado: (2015)

Autophagy termination and lysosome reformation regulated by mTOR
por: Yu, Li, et al.
Publicado: (2010)

mTOR's role in ageing: protein synthesis or autophagy?
por: Hands, Sarah L., et al.
Publicado: (2009)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Bufadienolides from Venenum Bufonis Inhibit mTOR-Mediated Cyclin D1 and Retinoblastoma Protein Leading to Arrest of Cell Cycle in Cancer Cells
por: Chang, Huamei, et al.
Publicado: (2018)

TOFA induces cell cycle arrest and apoptosis in ACHN and 786-O cells through inhibiting PI3K/Akt/mTOR pathway
por: He, Dejiao, et al.
Publicado: (2018)

Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells
por: Kim, Sojin, et al.
Publicado: (2020)

mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy
por: Madrakhimov, Sanjar Batirovich, et al.
Publicado: (2021)

Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
por: Wang, Feng, et al.
Publicado: (2015)

Glipizide sensitizes lung cancer cells to TRAIL-induced apoptosis via Akt/mTOR/autophagy pathways
por: Nazim, Uddin MD., et al.
Publicado: (2017)

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells
por: Hau, Andrew M., et al.
Publicado: (2013)

Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer
por: Sha, Min, et al.
Publicado: (2015)

PM2.5 induces cell cycle arrest through regulating mTOR/P70S6K1 signaling pathway
por: Zhang, Yu, et al.
Publicado: (2019)

Selenite Induces Cell Cycle Arrest and Apoptosis via Reactive Oxygen Species-Dependent Inhibition of the AKT/mTOR Pathway in Thyroid Cancer
por: Cheng, Zhen, et al.
Publicado: (2021)

Monensin blocks the transport of diphtheria toxin to the cell cytoplasm
Publicado: (1982)

Chrysin Induces Apoptosis and Autophagy in Human Melanoma Cells via the mTOR/S6K Pathway
por: Lee, Jae-Han, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ba91ajunl3ta76ob5amtnuk3qv