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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K(+) channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K(+) conductance could be connected...

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Detalles Bibliográficos
Autores principales: Hong, Seung Hwa, Sung, Rohyun, Kim, Young Chul, Suzuki, Hikaru, Choi, Woong, Park, Yeon Jin, Ji, Ill Woon, Kim, Chan Hyung, Myung, Sun Chul, Lee, Moo Yeol, Kang, Tong Mook, You, Ra Young, Lee, Kwang Ju, Lim, Seung Woon, Yun, Hyo-Yung, Song, Young-Jin, Xu, Wen-Xie, Kim, Hak Soon, Lee, Sang Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741493/
https://www.ncbi.nlm.nih.gov/pubmed/23946696
http://dx.doi.org/10.4196/kjpp.2013.17.4.359
Descripción
Sumario:Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K(+) channels. Because contractility of uterine muscle is regulated by extracellular pH and humoral factors, K(+) conductance could be connected to factors regulating uterine contractility during pregnancy. Here, we showed that TASK-2 inhibitors such as quinidine, lidocaine, and extracellular acidosis produced contraction in uterine circular muscle of mouse. Furthermore, contractility was significantly increased in pregnant uterine circular muscle than that of non-pregnant muscle. These patterns were not changed even in the presence of tetraetylammonium (TEA) and 4-aminopyridine (4-AP). Finally, TASK-2 inhibitors induced strong myometrial contraction even in the presence of L-methionine, a known inhibitor of stretchactivated channels in myometrium. When compared to non-pregnant myometrium, pregnant myometrium showed increased immunohistochemical expression of TASK-2. Therefore, TASK-2, seems to play a key role during regulation of myometrial contractility in the pregnancy and provides new insight into preventing preterm delivery.