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Functional role of ambient GABA in refining neuronal circuits early in postnatal development

Early in development, γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mature brain, depolarizes and excites targeted neurons by an outwardly directed flux of chloride, resulting from the peculiar balance between the cation-chloride importer NKCC1 and the extruder KCC2. The...

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Detalles Bibliográficos
Autores principales: Cellot, Giada, Cherubini, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741556/
https://www.ncbi.nlm.nih.gov/pubmed/23964205
http://dx.doi.org/10.3389/fncir.2013.00136