The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells....

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Detalles Bibliográficos
Autores principales: Jo, Wol Soon, Choi, Yoo Jin, Kim, Hyoun Ji, Lee, Jae Yun, Nam, Byung Hyouk, Lee, Jae Dong, Lee, Sang Wha, Seo, Su Yeong, Jeong, Min Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741594/
https://www.ncbi.nlm.nih.gov/pubmed/23956624
http://dx.doi.org/10.4489/MYCO.2010.38.1.046
Descripción
Sumario:The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-α and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.

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