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Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity generates PAR fragments. Here we present the cr...
Autores principales: | Barkauskaite, Eva, Brassington, Amy, Tan, Edwin S., Warwicker, Jim, Dunstan, Mark S., Banos, Benito, Lafite, Pierre, Ahel, Marijan, Mitchison, Timothy J., Ahel, Ivan, Leys, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741636/ https://www.ncbi.nlm.nih.gov/pubmed/23917065 http://dx.doi.org/10.1038/ncomms3164 |
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