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Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants
Objectives. The purpose of these studies was to understand the influence of cosolvent and surfactant contributions to particle size distributions emitted from solution metered dose inhalers (pMDIs) based on the propellant HFA 227. Methods. Two sets of formulations were prepared: (a) pMDIs-HFA 227 co...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741898/ https://www.ncbi.nlm.nih.gov/pubmed/23984381 http://dx.doi.org/10.1155/2013/574310 |
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author | Saleem, Imran Y. Smyth, Hugh D. C. |
author_facet | Saleem, Imran Y. Smyth, Hugh D. C. |
author_sort | Saleem, Imran Y. |
collection | PubMed |
description | Objectives. The purpose of these studies was to understand the influence of cosolvent and surfactant contributions to particle size distributions emitted from solution metered dose inhalers (pMDIs) based on the propellant HFA 227. Methods. Two sets of formulations were prepared: (a) pMDIs-HFA 227 containing cosolvent (5–15% w/w ethanol) with constant surfactant (pluronic) concentration and (b) pMDIs-HFA 227 containing surfactant (0–5.45% w/w pluronic) with constant cosolvent concentration. Particle size distributions emitted from these pMDIs were analyzed using aerodynamic characterization (inertial impaction) and laser diffraction methods. Results. Both cosolvent and surfactant concentrations were positively correlated with median particle sizes; that is, drug particle size increased with increasing ethanol and pluronic concentrations. However, evaluation of particle size distributions showed that cosolvent caused reduction in the fine particle mode magnitude while the surfactant caused a shift in the mode position. These findings highlight the different mechanisms by which these components influence droplet formation and demonstrate the ability to utilize the different effects in formulations of pMDI-HFA 227 for independently modulating particle sizes in the respirable region. Conclusion. Potentially, the formulation design window generated using these excipients in combination could be used to match the particle size output of reformulated products to preexisting pMDI products. |
format | Online Article Text |
id | pubmed-3741898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37418982013-08-27 Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants Saleem, Imran Y. Smyth, Hugh D. C. Biomed Res Int Research Article Objectives. The purpose of these studies was to understand the influence of cosolvent and surfactant contributions to particle size distributions emitted from solution metered dose inhalers (pMDIs) based on the propellant HFA 227. Methods. Two sets of formulations were prepared: (a) pMDIs-HFA 227 containing cosolvent (5–15% w/w ethanol) with constant surfactant (pluronic) concentration and (b) pMDIs-HFA 227 containing surfactant (0–5.45% w/w pluronic) with constant cosolvent concentration. Particle size distributions emitted from these pMDIs were analyzed using aerodynamic characterization (inertial impaction) and laser diffraction methods. Results. Both cosolvent and surfactant concentrations were positively correlated with median particle sizes; that is, drug particle size increased with increasing ethanol and pluronic concentrations. However, evaluation of particle size distributions showed that cosolvent caused reduction in the fine particle mode magnitude while the surfactant caused a shift in the mode position. These findings highlight the different mechanisms by which these components influence droplet formation and demonstrate the ability to utilize the different effects in formulations of pMDI-HFA 227 for independently modulating particle sizes in the respirable region. Conclusion. Potentially, the formulation design window generated using these excipients in combination could be used to match the particle size output of reformulated products to preexisting pMDI products. Hindawi Publishing Corporation 2013 2013-07-24 /pmc/articles/PMC3741898/ /pubmed/23984381 http://dx.doi.org/10.1155/2013/574310 Text en Copyright © 2013 I. Y. Saleem and H. D. C. Smyth. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Saleem, Imran Y. Smyth, Hugh D. C. Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title | Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title_full | Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title_fullStr | Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title_full_unstemmed | Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title_short | Tuning Aerosol Particle Size Distribution of Metered Dose Inhalers Using Cosolvents and Surfactants |
title_sort | tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741898/ https://www.ncbi.nlm.nih.gov/pubmed/23984381 http://dx.doi.org/10.1155/2013/574310 |
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