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Celiac Disease and Autoimmune-Associated Conditions

Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a...

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Autores principales: Lauret, Eugenia, Rodrigo, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741914/
https://www.ncbi.nlm.nih.gov/pubmed/23984314
http://dx.doi.org/10.1155/2013/127589
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author Lauret, Eugenia
Rodrigo, Luis
author_facet Lauret, Eugenia
Rodrigo, Luis
author_sort Lauret, Eugenia
collection PubMed
description Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.
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spelling pubmed-37419142013-08-27 Celiac Disease and Autoimmune-Associated Conditions Lauret, Eugenia Rodrigo, Luis Biomed Res Int Review Article Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage. Hindawi Publishing Corporation 2013 2013-07-24 /pmc/articles/PMC3741914/ /pubmed/23984314 http://dx.doi.org/10.1155/2013/127589 Text en Copyright © 2013 E. Lauret and L. Rodrigo. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lauret, Eugenia
Rodrigo, Luis
Celiac Disease and Autoimmune-Associated Conditions
title Celiac Disease and Autoimmune-Associated Conditions
title_full Celiac Disease and Autoimmune-Associated Conditions
title_fullStr Celiac Disease and Autoimmune-Associated Conditions
title_full_unstemmed Celiac Disease and Autoimmune-Associated Conditions
title_short Celiac Disease and Autoimmune-Associated Conditions
title_sort celiac disease and autoimmune-associated conditions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741914/
https://www.ncbi.nlm.nih.gov/pubmed/23984314
http://dx.doi.org/10.1155/2013/127589
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