A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()

A newly identified human locus on chromosome 15 was recently associated with zinc accumulation. Based on a prior report of a threefold difference in zinc accumulation between fumble(1) heterozygous mutants and control fly strains, it was suggested that phosphopantothenoylcysteine decarboxylase might...

Descripción completa

Detalles Bibliográficos
Autores principales: Afshar, Negar, Argunhan, Bilge, Bettedi, Lucia, Szular, Joanna, Missirlis, Fanis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741916/
https://www.ncbi.nlm.nih.gov/pubmed/23951551
http://dx.doi.org/10.1016/j.fob.2013.07.003
_version_ 1782280295829995520
author Afshar, Negar
Argunhan, Bilge
Bettedi, Lucia
Szular, Joanna
Missirlis, Fanis
author_facet Afshar, Negar
Argunhan, Bilge
Bettedi, Lucia
Szular, Joanna
Missirlis, Fanis
author_sort Afshar, Negar
collection PubMed
description A newly identified human locus on chromosome 15 was recently associated with zinc accumulation. Based on a prior report of a threefold difference in zinc accumulation between fumble(1) heterozygous mutants and control fly strains, it was suggested that phosphopantothenoylcysteine decarboxylase might affect zinc status through its effects on vitamin B5 (pantothenate) metabolism. We report here that outcrossed fumble(1) heterozygous mutant flies with low zinc content have been recovered, suggesting that pantothenate metabolism did not alter zinc homeostasis in fumble(1) heterozygous flies. We show instead that the Drosophila condition of low body zinc accumulation is an X-chromosome-linked recessive trait.
format Online
Article
Text
id pubmed-3741916
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-37419162013-08-15 A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains() Afshar, Negar Argunhan, Bilge Bettedi, Lucia Szular, Joanna Missirlis, Fanis FEBS Open Bio Article A newly identified human locus on chromosome 15 was recently associated with zinc accumulation. Based on a prior report of a threefold difference in zinc accumulation between fumble(1) heterozygous mutants and control fly strains, it was suggested that phosphopantothenoylcysteine decarboxylase might affect zinc status through its effects on vitamin B5 (pantothenate) metabolism. We report here that outcrossed fumble(1) heterozygous mutant flies with low zinc content have been recovered, suggesting that pantothenate metabolism did not alter zinc homeostasis in fumble(1) heterozygous flies. We show instead that the Drosophila condition of low body zinc accumulation is an X-chromosome-linked recessive trait. Elsevier 2013-07-24 /pmc/articles/PMC3741916/ /pubmed/23951551 http://dx.doi.org/10.1016/j.fob.2013.07.003 Text en © 2013 The Authors http://creativecommons.org/licenses/BY-license/3.0/ This is an open-access article distributed under the terms of the Creative CommonsAttribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Afshar, Negar
Argunhan, Bilge
Bettedi, Lucia
Szular, Joanna
Missirlis, Fanis
A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title_full A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title_fullStr A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title_full_unstemmed A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title_short A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains()
title_sort recessive x-linked mutation causes a threefold reduction of total body zinc accumulation in drosophila melanogaster laboratory strains()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741916/
https://www.ncbi.nlm.nih.gov/pubmed/23951551
http://dx.doi.org/10.1016/j.fob.2013.07.003
work_keys_str_mv AT afsharnegar arecessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT argunhanbilge arecessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT bettedilucia arecessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT szularjoanna arecessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT missirlisfanis arecessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT afsharnegar recessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT argunhanbilge recessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT bettedilucia recessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT szularjoanna recessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains
AT missirlisfanis recessivexlinkedmutationcausesathreefoldreductionoftotalbodyzincaccumulationindrosophilamelanogasterlaboratorystrains

Ejemplares similares