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Genetics of Alzheimer's Disease
Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741956/ https://www.ncbi.nlm.nih.gov/pubmed/23984328 http://dx.doi.org/10.1155/2013/254954 |
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author | Ridge, Perry G. Ebbert, Mark T. W. Kauwe, John S. K. |
author_facet | Ridge, Perry G. Ebbert, Mark T. W. Kauwe, John S. K. |
author_sort | Ridge, Perry G. |
collection | PubMed |
description | Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease. |
format | Online Article Text |
id | pubmed-3741956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37419562013-08-27 Genetics of Alzheimer's Disease Ridge, Perry G. Ebbert, Mark T. W. Kauwe, John S. K. Biomed Res Int Review Article Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease. Hindawi Publishing Corporation 2013 2013-07-25 /pmc/articles/PMC3741956/ /pubmed/23984328 http://dx.doi.org/10.1155/2013/254954 Text en Copyright © 2013 Perry G. Ridge et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ridge, Perry G. Ebbert, Mark T. W. Kauwe, John S. K. Genetics of Alzheimer's Disease |
title | Genetics of Alzheimer's Disease |
title_full | Genetics of Alzheimer's Disease |
title_fullStr | Genetics of Alzheimer's Disease |
title_full_unstemmed | Genetics of Alzheimer's Disease |
title_short | Genetics of Alzheimer's Disease |
title_sort | genetics of alzheimer's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741956/ https://www.ncbi.nlm.nih.gov/pubmed/23984328 http://dx.doi.org/10.1155/2013/254954 |
work_keys_str_mv | AT ridgeperryg geneticsofalzheimersdisease AT ebbertmarktw geneticsofalzheimersdisease AT kauwejohnsk geneticsofalzheimersdisease |