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The Controversial Role of Microglia in Malignant Gliomas

Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs c...

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Detalles Bibliográficos
Autores principales: Wei, Jun, Gabrusiewicz, Konrad, Heimberger, Amy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741958/
https://www.ncbi.nlm.nih.gov/pubmed/23983766
http://dx.doi.org/10.1155/2013/285246
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author Wei, Jun
Gabrusiewicz, Konrad
Heimberger, Amy
author_facet Wei, Jun
Gabrusiewicz, Konrad
Heimberger, Amy
author_sort Wei, Jun
collection PubMed
description Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions.
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spelling pubmed-37419582013-08-27 The Controversial Role of Microglia in Malignant Gliomas Wei, Jun Gabrusiewicz, Konrad Heimberger, Amy Clin Dev Immunol Review Article Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions. Hindawi Publishing Corporation 2013 2013-07-24 /pmc/articles/PMC3741958/ /pubmed/23983766 http://dx.doi.org/10.1155/2013/285246 Text en Copyright © 2013 Jun Wei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wei, Jun
Gabrusiewicz, Konrad
Heimberger, Amy
The Controversial Role of Microglia in Malignant Gliomas
title The Controversial Role of Microglia in Malignant Gliomas
title_full The Controversial Role of Microglia in Malignant Gliomas
title_fullStr The Controversial Role of Microglia in Malignant Gliomas
title_full_unstemmed The Controversial Role of Microglia in Malignant Gliomas
title_short The Controversial Role of Microglia in Malignant Gliomas
title_sort controversial role of microglia in malignant gliomas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741958/
https://www.ncbi.nlm.nih.gov/pubmed/23983766
http://dx.doi.org/10.1155/2013/285246
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