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The Controversial Role of Microglia in Malignant Gliomas
Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs c...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741958/ https://www.ncbi.nlm.nih.gov/pubmed/23983766 http://dx.doi.org/10.1155/2013/285246 |
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author | Wei, Jun Gabrusiewicz, Konrad Heimberger, Amy |
author_facet | Wei, Jun Gabrusiewicz, Konrad Heimberger, Amy |
author_sort | Wei, Jun |
collection | PubMed |
description | Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions. |
format | Online Article Text |
id | pubmed-3741958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37419582013-08-27 The Controversial Role of Microglia in Malignant Gliomas Wei, Jun Gabrusiewicz, Konrad Heimberger, Amy Clin Dev Immunol Review Article Malignant gliomas contain stroma and a variety of immune cells including abundant activated microglia/macrophages. Mounting evidence indicates that the glioma microenvironment converts the glioma-associated microglia/macrophages (GAMs) into glioma-supportive, immunosuppressive cells; however, GAMs can retain intrinsic anti-tumor properties. Here, we review and discuss this duality and the potential therapeutic strategies that may inhibit their glioma-supportive and propagating functions. Hindawi Publishing Corporation 2013 2013-07-24 /pmc/articles/PMC3741958/ /pubmed/23983766 http://dx.doi.org/10.1155/2013/285246 Text en Copyright © 2013 Jun Wei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wei, Jun Gabrusiewicz, Konrad Heimberger, Amy The Controversial Role of Microglia in Malignant Gliomas |
title | The Controversial Role of Microglia in Malignant Gliomas |
title_full | The Controversial Role of Microglia in Malignant Gliomas |
title_fullStr | The Controversial Role of Microglia in Malignant Gliomas |
title_full_unstemmed | The Controversial Role of Microglia in Malignant Gliomas |
title_short | The Controversial Role of Microglia in Malignant Gliomas |
title_sort | controversial role of microglia in malignant gliomas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741958/ https://www.ncbi.nlm.nih.gov/pubmed/23983766 http://dx.doi.org/10.1155/2013/285246 |
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