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Renal disease masquerading as pyrexia of unknown origin

Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigati...

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Autores principales: Korivi, D., Billa, V., Patel, K., Madiwale, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741981/
https://www.ncbi.nlm.nih.gov/pubmed/23960353
http://dx.doi.org/10.4103/0971-4065.114491
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author Korivi, D.
Billa, V.
Patel, K.
Madiwale, C.
author_facet Korivi, D.
Billa, V.
Patel, K.
Madiwale, C.
author_sort Korivi, D.
collection PubMed
description Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigations led to a kidney biopsy which clinched the cause of his fever as well as the underlying diagnosis. The light microscopy findings of expansile storiform fibrosis with a dense inflammatory infiltrate suggested the diagnosis which was confirmed by positive staining of Immunoglobulin G4, the dense lympho-plasmacytic infiltrate and elevated serum IgG4 concentrations. A course of steroids followed by mycophenolate mofetil as maintenance immunosuppression rendered the patient afebrile with improvement of renal function.
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spelling pubmed-37419812013-08-19 Renal disease masquerading as pyrexia of unknown origin Korivi, D. Billa, V. Patel, K. Madiwale, C. Indian J Nephrol Case Report Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigations led to a kidney biopsy which clinched the cause of his fever as well as the underlying diagnosis. The light microscopy findings of expansile storiform fibrosis with a dense inflammatory infiltrate suggested the diagnosis which was confirmed by positive staining of Immunoglobulin G4, the dense lympho-plasmacytic infiltrate and elevated serum IgG4 concentrations. A course of steroids followed by mycophenolate mofetil as maintenance immunosuppression rendered the patient afebrile with improvement of renal function. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3741981/ /pubmed/23960353 http://dx.doi.org/10.4103/0971-4065.114491 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Korivi, D.
Billa, V.
Patel, K.
Madiwale, C.
Renal disease masquerading as pyrexia of unknown origin
title Renal disease masquerading as pyrexia of unknown origin
title_full Renal disease masquerading as pyrexia of unknown origin
title_fullStr Renal disease masquerading as pyrexia of unknown origin
title_full_unstemmed Renal disease masquerading as pyrexia of unknown origin
title_short Renal disease masquerading as pyrexia of unknown origin
title_sort renal disease masquerading as pyrexia of unknown origin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741981/
https://www.ncbi.nlm.nih.gov/pubmed/23960353
http://dx.doi.org/10.4103/0971-4065.114491
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