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Renal disease masquerading as pyrexia of unknown origin
Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741981/ https://www.ncbi.nlm.nih.gov/pubmed/23960353 http://dx.doi.org/10.4103/0971-4065.114491 |
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author | Korivi, D. Billa, V. Patel, K. Madiwale, C. |
author_facet | Korivi, D. Billa, V. Patel, K. Madiwale, C. |
author_sort | Korivi, D. |
collection | PubMed |
description | Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigations led to a kidney biopsy which clinched the cause of his fever as well as the underlying diagnosis. The light microscopy findings of expansile storiform fibrosis with a dense inflammatory infiltrate suggested the diagnosis which was confirmed by positive staining of Immunoglobulin G4, the dense lympho-plasmacytic infiltrate and elevated serum IgG4 concentrations. A course of steroids followed by mycophenolate mofetil as maintenance immunosuppression rendered the patient afebrile with improvement of renal function. |
format | Online Article Text |
id | pubmed-3741981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37419812013-08-19 Renal disease masquerading as pyrexia of unknown origin Korivi, D. Billa, V. Patel, K. Madiwale, C. Indian J Nephrol Case Report Pyrexia of unknown origin is a challenging clinical problem. Infections, malignancies, and connective tissue diseases form the major etiologies for this condition. We report a case of a 57-year-old diabetic male who presented with fever of unknown origin for several months. The course of investigations led to a kidney biopsy which clinched the cause of his fever as well as the underlying diagnosis. The light microscopy findings of expansile storiform fibrosis with a dense inflammatory infiltrate suggested the diagnosis which was confirmed by positive staining of Immunoglobulin G4, the dense lympho-plasmacytic infiltrate and elevated serum IgG4 concentrations. A course of steroids followed by mycophenolate mofetil as maintenance immunosuppression rendered the patient afebrile with improvement of renal function. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3741981/ /pubmed/23960353 http://dx.doi.org/10.4103/0971-4065.114491 Text en Copyright: © Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Korivi, D. Billa, V. Patel, K. Madiwale, C. Renal disease masquerading as pyrexia of unknown origin |
title | Renal disease masquerading as pyrexia of unknown origin |
title_full | Renal disease masquerading as pyrexia of unknown origin |
title_fullStr | Renal disease masquerading as pyrexia of unknown origin |
title_full_unstemmed | Renal disease masquerading as pyrexia of unknown origin |
title_short | Renal disease masquerading as pyrexia of unknown origin |
title_sort | renal disease masquerading as pyrexia of unknown origin |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741981/ https://www.ncbi.nlm.nih.gov/pubmed/23960353 http://dx.doi.org/10.4103/0971-4065.114491 |
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