Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with las...

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Detalles Bibliográficos
Autores principales: Blazkova, Iva, Nguyen, Hoai Viet, Dostalova, Simona, Kopel, Pavel, Stanisavljevic, Maja, Vaculovicova, Marketa, Stiborova, Marie, Eckschlager, Tomas, Kizek, Rene, Adam, Vojtech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742193/
https://www.ncbi.nlm.nih.gov/pubmed/23807501
http://dx.doi.org/10.3390/ijms140713391
Descripción
Sumario:Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.

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