Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery

Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with las...

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Autores principales: Blazkova, Iva, Nguyen, Hoai Viet, Dostalova, Simona, Kopel, Pavel, Stanisavljevic, Maja, Vaculovicova, Marketa, Stiborova, Marie, Eckschlager, Tomas, Kizek, Rene, Adam, Vojtech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742193/
https://www.ncbi.nlm.nih.gov/pubmed/23807501
http://dx.doi.org/10.3390/ijms140713391
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author Blazkova, Iva
Nguyen, Hoai Viet
Dostalova, Simona
Kopel, Pavel
Stanisavljevic, Maja
Vaculovicova, Marketa
Stiborova, Marie
Eckschlager, Tomas
Kizek, Rene
Adam, Vojtech
author_facet Blazkova, Iva
Nguyen, Hoai Viet
Dostalova, Simona
Kopel, Pavel
Stanisavljevic, Maja
Vaculovicova, Marketa
Stiborova, Marie
Eckschlager, Tomas
Kizek, Rene
Adam, Vojtech
author_sort Blazkova, Iva
collection PubMed
description Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution.
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spelling pubmed-37421932013-08-13 Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery Blazkova, Iva Nguyen, Hoai Viet Dostalova, Simona Kopel, Pavel Stanisavljevic, Maja Vaculovicova, Marketa Stiborova, Marie Eckschlager, Tomas Kizek, Rene Adam, Vojtech Int J Mol Sci Article Magnetic particle mediated transport in combination with nanomaterial based drug carrier has a great potential for targeted cancer therapy. In this study, doxorubicin encapsulation into the apoferritin and its conjugation with magnetic particles was investigated by capillary electrophoresis with laser-induced fluorescence detection (CE-LIF). The quantification of encapsulated doxorubicin was performed by fluorescence spectroscopy and compared to CE-LIF. Moreover, the significant enhancement of the doxorubicin signal was observed by addition of methanol into the sample solution. Molecular Diversity Preservation International (MDPI) 2013-06-27 /pmc/articles/PMC3742193/ /pubmed/23807501 http://dx.doi.org/10.3390/ijms140713391 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Blazkova, Iva
Nguyen, Hoai Viet
Dostalova, Simona
Kopel, Pavel
Stanisavljevic, Maja
Vaculovicova, Marketa
Stiborova, Marie
Eckschlager, Tomas
Kizek, Rene
Adam, Vojtech
Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title_full Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title_fullStr Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title_full_unstemmed Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title_short Apoferritin Modified Magnetic Particles as Doxorubicin Carriers for Anticancer Drug Delivery
title_sort apoferritin modified magnetic particles as doxorubicin carriers for anticancer drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742193/
https://www.ncbi.nlm.nih.gov/pubmed/23807501
http://dx.doi.org/10.3390/ijms140713391
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