Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in iso...

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Detalles Bibliográficos
Autores principales: Turpeinen, Miia, Uusitalo, Jouko, Lehtinen, Terhi, Kailajärvi, Marita, Pelkonen, Olavi, Vuorinen, Jouni, Tapanainen, Pasi, Stjernschantz, Camilla, Lammintausta, Risto, Scheinin, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742231/
https://www.ncbi.nlm.nih.gov/pubmed/23880855
http://dx.doi.org/10.3390/ijms140714064

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