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miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases
Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are currently thought to repress DNA methylation and supp...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742264/ https://www.ncbi.nlm.nih.gov/pubmed/23857059 http://dx.doi.org/10.3390/ijms140714647 |
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author | Morita, Sumiyo Horii, Takuro Kimura, Mika Ochiya, Takahiro Tajima, Shoji Hatada, Izuho |
author_facet | Morita, Sumiyo Horii, Takuro Kimura, Mika Ochiya, Takahiro Tajima, Shoji Hatada, Izuho |
author_sort | Morita, Sumiyo |
collection | PubMed |
description | Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are currently thought to repress DNA methylation and suppress tumorigenesis by protecting against de novo methylation. Here, we report that members of the miR-29 family repress the activities of DNA methyltransferases and DNA demethylases, which have opposing roles in control of DNA methylation status. Members of the miR-29 family directly inhibited DNA methyltransferases and two major factors involved in DNA demethylation, namely tet methylcytosine dioxygenase 1 (TET1) and thymine DNA glycosylase (TDG). Overexpression of miR-29 upregulated the global DNA methylation level in some cancer cells and downregulated DNA methylation in other cancer cells, suggesting that miR-29 suppresses tumorigenesis by protecting against changes in the existing DNA methylation status rather than by preventing de novo methylation of DNA. |
format | Online Article Text |
id | pubmed-3742264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-37422642013-08-13 miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases Morita, Sumiyo Horii, Takuro Kimura, Mika Ochiya, Takahiro Tajima, Shoji Hatada, Izuho Int J Mol Sci Article Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are currently thought to repress DNA methylation and suppress tumorigenesis by protecting against de novo methylation. Here, we report that members of the miR-29 family repress the activities of DNA methyltransferases and DNA demethylases, which have opposing roles in control of DNA methylation status. Members of the miR-29 family directly inhibited DNA methyltransferases and two major factors involved in DNA demethylation, namely tet methylcytosine dioxygenase 1 (TET1) and thymine DNA glycosylase (TDG). Overexpression of miR-29 upregulated the global DNA methylation level in some cancer cells and downregulated DNA methylation in other cancer cells, suggesting that miR-29 suppresses tumorigenesis by protecting against changes in the existing DNA methylation status rather than by preventing de novo methylation of DNA. Molecular Diversity Preservation International (MDPI) 2013-07-12 /pmc/articles/PMC3742264/ /pubmed/23857059 http://dx.doi.org/10.3390/ijms140714647 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Morita, Sumiyo Horii, Takuro Kimura, Mika Ochiya, Takahiro Tajima, Shoji Hatada, Izuho miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title | miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title_full | miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title_fullStr | miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title_full_unstemmed | miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title_short | miR-29 Represses the Activities of DNA Methyltransferases and DNA Demethylases |
title_sort | mir-29 represses the activities of dna methyltransferases and dna demethylases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742264/ https://www.ncbi.nlm.nih.gov/pubmed/23857059 http://dx.doi.org/10.3390/ijms140714647 |
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