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Analysis of UGT1A1*28 genotype and SN-38 pharmacokinetics for irinotecan-based chemotherapy in patients with advanced colorectal cancer: results from a multicenter, retrospective study in Shanghai

BACKGROUND: The UGT1A1*28 polymorphism, although closely linked with CPT-11-related adverse effects, cannot be used alone to guide individualized treatment decisions. However, CPT-11 dosage can be adjusted according to measured SN-38 pharmacokinetics. Our study is designed to investigate whether the...

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Detalles Bibliográficos
Autores principales:	Cai, Xun, Cao, Weiguo, Ding, Honghua, Liu, Tianshu, Zhou, Xinli, Wang, Mei, Zhong, Ming, Zhao, Ziyi, Xu, Qing, Wang, Liwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742415/ https://www.ncbi.nlm.nih.gov/pubmed/23892411 http://dx.doi.org/10.1007/s00432-013-1480-7

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