Cargando…

Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells

The present study aimed to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) and MDR1/P-glycoprotein (P-gp) in human laryngeal squamous cell carcinoma (LSCC) tissues, and also to investigate the regulation of MDR1 gene expression by HIF-1α in Hep-2 cells under hypoxic conditions. The e...

Descripción completa

Detalles Bibliográficos
Autores principales:	XIE, JIN, LI, DA-WEI, CHEN, XIN-WEI, WANG, FEI, DONG, PIN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742502/ https://www.ncbi.nlm.nih.gov/pubmed/23946810 http://dx.doi.org/10.3892/ol.2013.1321

Ejemplares similares

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
por: Ding, Zhenyu, et al.
Publicado: (2010)

Expression of MDR1/P glycoprotein in human sarcomas.
por: Vergier, B., et al.
Publicado: (1993)

Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
por: Dupuis, Maria Luisa, et al.
Publicado: (2013)

Influence of RARα gene on MDR1 expression and P-glycoprotein function in human leukemic cells
por: Stromskaya, Tatjana P, et al.
Publicado: (2005)

Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance
por: Surowiak, Pawel, et al.
Publicado: (2005)

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
por: Asperen, J van, et al.
Publicado: (1999)

Correlation between the expression of divalent metal transporter 1 and the content of hypoxia-inducible factor-1 in hypoxic HepG2 cells
por: Li, Zhu, et al.
Publicado: (2008)

HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein
por: Chen, Jianfang, et al.
Publicado: (2014)

The Expression of Hypoxia-Related Biomarkers: A Significance of HIF-1α C1772T Polymorphism as Predictor of Laryngeal Carcinoma Relapse
por: Folic, Miljan M., et al.
Publicado: (2022)

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
por: Cianfriglia, Maurizio, et al.
Publicado: (2007)

Catalytic Transitions in the Human MDR1 P-Glycoprotein Drug Binding Sites
por: Wise, John G.
Publicado: (2012)

Expression and significance of glucose transporter-1, P-glycoprotein, multidrug resistance-associated protein and glutathione S-transferase-π in laryngeal carcinoma
por: MAO, ZHONG-PING, et al.
Publicado: (2015)

P-Glycoprotein/MDR1 Regulates Pokemon Gene Transcription Through p53 Expression in Human Breast Cancer Cells
por: He, Shengnan, et al.
Publicado: (2010)

Expression of DNA topoisomerase II-α: Clinical significance in laryngeal carcinoma
por: FENG, YAN, et al.
Publicado: (2014)

mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells
por: Kuo, Chung-Wen, et al.
Publicado: (2017)

Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients
por: Surono, Agus, et al.
Publicado: (2016)

Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells
por: Xu, Dan, et al.
Publicado: (2019)

Prognostic significance of artemin and GFRα1 expression in laryngeal squamous cell carcinoma
por: GAO, CHAOBING, et al.
Publicado: (2014)

Oxymatrine Downregulates HPV16E7 Expression and Inhibits Cell Proliferation in Laryngeal Squamous Cell Carcinoma Hep-2 Cells In Vitro
por: Ying, Xin-Jiang, et al.
Publicado: (2015)

C-fos upregulates P-glycoprotein, contributing to the development of multidrug resistance in HEp-2 laryngeal cancer cells with VCR-induced resistance
por: Li, Guodong, et al.
Publicado: (2018)

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
por: Brenn, Anja, et al.
Publicado: (2011)

Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia-ischemia
por: Sheldon, R. Ann, et al.
Publicado: (2014)

Sclareol Inhibits Hypoxia-Inducible Factor-1α Accumulation and Induces Apoptosis in Hypoxic Cancer Cells
por: Vandghanooni, Somayeh, et al.
Publicado: (2022)

Hypoxia-inducible factor-1α and Wnt/β-catenin signaling pathways promote the invasion of hypoxic gastric cancer cells
por: LIU, HONG-LAN, et al.
Publicado: (2015)

Regulation of hypoxia inducible factor-1α expression by the alteration of redox status in HepG2 cells
por: Jin, Wen-sen, et al.
Publicado: (2011)

Inhibitory Effects of Neochamaejasmin B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein
por: Pan, Lanying, et al.
Publicado: (2015)

Krüppel-like factor 8 contributes to hypoxia-induced MDR in gastric cancer cells
por: Zhang, Hui, et al.
Publicado: (2014)

Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1
por: Hassan, Sarah, et al.
Publicado: (2020)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918
por: Wallstab, A, et al.
Publicado: (1999)

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA
por: Pluchino, Kristen M., et al.
Publicado: (2015)

Association between MDR1 gene of gastrointestinal tumors, the expression of P-glycoprotein and resistance to chemotherapeutic drugs
por: Su, Jian-Li, et al.
Publicado: (2017)

Quantitative Structure–Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells
por: Xia, Mengmeng, et al.
Publicado: (2019)

Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression
por: Guo, Hongchun, et al.
Publicado: (2020)

Prognostic significance of soft tissue deposits in laryngeal carcinoma()
por: Ozmen, Omer Afsin, et al.
Publicado: (2017)

Significance of hypoxia-inducible factor-1α expression with atrial fibrosis in rats induced with isoproterenol
por: SU, FANGJU, et al.
Publicado: (2014)

Association between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia
por: Geers, Lisanne M., et al.
Publicado: (2020)

Exercise induces tissue hypoxia and HIF-1α redistribution in the small intestine
por: Wu, Die, et al.
Publicado: (2020)

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport
por: Sadiq, Muhammad Waqas, et al.
Publicado: (2015)

Astragaloside IV improves angiogenesis under hypoxic conditions by enhancing hypoxia-inducible factor-1α SUMOylation
por: Wang, Baoshen, et al.
Publicado: (2021)

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
por: Martí, Juan Manuel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_arvpsbupiu61utq5bgghcbv4m4