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Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008

To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005–2008. Blood specimens were collected from 87 household members and 332 social contacts of 23...

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Autores principales: Liao, Qiaohong, Bai, Tian, Zhou, Lei, Vong, Sirenda, Guo, Junqiao, Lv, Wei, Dong, Libo, Xiang, Nijuan, Li, Zi, Huai, Yang, Zhou, Jianfang, Li, Xiaodan, Chen, Ray Y., Xu, Zhen, Uyeki, Timothy M., Shu, Yuelong, Yu, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742513/
https://www.ncbi.nlm.nih.gov/pubmed/23967241
http://dx.doi.org/10.1371/journal.pone.0071765
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author Liao, Qiaohong
Bai, Tian
Zhou, Lei
Vong, Sirenda
Guo, Junqiao
Lv, Wei
Dong, Libo
Xiang, Nijuan
Li, Zi
Huai, Yang
Zhou, Jianfang
Li, Xiaodan
Chen, Ray Y.
Xu, Zhen
Uyeki, Timothy M.
Shu, Yuelong
Yu, Hongjie
author_facet Liao, Qiaohong
Bai, Tian
Zhou, Lei
Vong, Sirenda
Guo, Junqiao
Lv, Wei
Dong, Libo
Xiang, Nijuan
Li, Zi
Huai, Yang
Zhou, Jianfang
Li, Xiaodan
Chen, Ray Y.
Xu, Zhen
Uyeki, Timothy M.
Shu, Yuelong
Yu, Hongjie
author_sort Liao, Qiaohong
collection PubMed
description To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005–2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case’s infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005–2008 were not easily transmitted to close contacts of H5N1 cases.
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spelling pubmed-37425132013-08-21 Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008 Liao, Qiaohong Bai, Tian Zhou, Lei Vong, Sirenda Guo, Junqiao Lv, Wei Dong, Libo Xiang, Nijuan Li, Zi Huai, Yang Zhou, Jianfang Li, Xiaodan Chen, Ray Y. Xu, Zhen Uyeki, Timothy M. Shu, Yuelong Yu, Hongjie PLoS One Research Article To assess the extent of highly pathogenic avian influenza (HPAI) A (H5N1) virus transmission, we conducted sero-epidemiologic studies among close contacts exposed to H5N1 cases in mainland China during 2005–2008. Blood specimens were collected from 87 household members and 332 social contacts of 23 H5N1 index cases for HPAI H5N1 serological testing by modified horse red-blood-cell hemagglutinin inhibition and microneutralization assays. All participants were interviewed with a standardized questionnaire to collect information about the use of personal protective equipment, illness symptoms, exposure to an H5N1 case during the infectious period, and poultry exposures. Two (2.3%) household contacts tested positive for HPAI H5N1 virus antibody, and all social contacts tested negative. Both seropositive cases had prolonged, unprotected, close contact with a different H5N1 index case, including days of bed-care or sleeping together during the index case’s infectious period, and did not develop any illness. None of the 419 close contacts used appropriate personal protective equipment including 17% who reported providing bedside care or having physical contact with an H5N1 case for at least 12 hours. Our findings suggest that HPAI H5N1 viruses that circulated among poultry in mainland China from 2005–2008 were not easily transmitted to close contacts of H5N1 cases. Public Library of Science 2013-08-13 /pmc/articles/PMC3742513/ /pubmed/23967241 http://dx.doi.org/10.1371/journal.pone.0071765 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Liao, Qiaohong
Bai, Tian
Zhou, Lei
Vong, Sirenda
Guo, Junqiao
Lv, Wei
Dong, Libo
Xiang, Nijuan
Li, Zi
Huai, Yang
Zhou, Jianfang
Li, Xiaodan
Chen, Ray Y.
Xu, Zhen
Uyeki, Timothy M.
Shu, Yuelong
Yu, Hongjie
Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title_full Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title_fullStr Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title_full_unstemmed Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title_short Seroprevalence of Antibodies to Highly Pathogenic Avian Influenza A (H5N1) Virus among Close Contacts Exposed to H5N1 Cases, China, 2005–2008
title_sort seroprevalence of antibodies to highly pathogenic avian influenza a (h5n1) virus among close contacts exposed to h5n1 cases, china, 2005–2008
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742513/
https://www.ncbi.nlm.nih.gov/pubmed/23967241
http://dx.doi.org/10.1371/journal.pone.0071765
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