The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase

One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understa...

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Detalles Bibliográficos
Autores principales: Shang, Qian, Xiang, Junfeng, Zhang, Hong, Li, Qian, Tang, Yalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742645/
https://www.ncbi.nlm.nih.gov/pubmed/23967118
http://dx.doi.org/10.1371/journal.pone.0070841
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author Shang, Qian
Xiang, Junfeng
Zhang, Hong
Li, Qian
Tang, Yalin
author_facet Shang, Qian
Xiang, Junfeng
Zhang, Hong
Li, Qian
Tang, Yalin
author_sort Shang, Qian
collection PubMed
description One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.
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spelling pubmed-37426452013-08-21 The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase Shang, Qian Xiang, Junfeng Zhang, Hong Li, Qian Tang, Yalin PLoS One Research Article One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes. Public Library of Science 2013-08-13 /pmc/articles/PMC3742645/ /pubmed/23967118 http://dx.doi.org/10.1371/journal.pone.0070841 Text en © 2013 Shang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shang, Qian
Xiang, Junfeng
Zhang, Hong
Li, Qian
Tang, Yalin
The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title_full The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title_fullStr The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title_full_unstemmed The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title_short The Effect of Polyhydroxylated Alkaloids on Maltase-Glucoamylase
title_sort effect of polyhydroxylated alkaloids on maltase-glucoamylase
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742645/
https://www.ncbi.nlm.nih.gov/pubmed/23967118
http://dx.doi.org/10.1371/journal.pone.0070841
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