Mathematical Model of Bursting in Dissociated Purkinje Neurons

In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinj...

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Detalles Bibliográficos
Autor principal: Forrest, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742666/
https://www.ncbi.nlm.nih.gov/pubmed/23967054
http://dx.doi.org/10.1371/journal.pone.0068765
Descripción
Sumario:In vitro, Purkinje cell behaviour is sometimes studied in a dissociated soma preparation in which the dendritic projection has been cleaved. A fraction of these dissociated somas spontaneously burst. The mechanism of this bursting is incompletely understood. We have constructed a biophysical Purkinje soma model, guided and constrained by experimental reports in the literature, that can replicate the somatically driven bursting pattern and which hypothesises Persistent Na(+) current (I(NaP)) to be its burst initiator and SK K(+) current (I(SK)) to be its burst terminator.

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