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Clinical significance of CD24 as a predictor of bladder cancer recurrence

Cluster of differentiation (CD)24 was originally described as a B lymphocyte marker and has recently received considerable attention in cancer research as its overexpression has been observed in several types of carcinoma. The CD24 molecule is a glycosyl-phosphatidylinositol-linked cell surface prot...

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Autores principales: LIU, CHUNXIAO, ZHENG, SHAOBO, SHEN, HAIYAN, XU, KAI, CHEN, JIE, LI, HULIN, XU, YAWEN, XU, ABAI, CHEN, BINSHEN, KAKU, HARUKI, NASU, YASUTOMO, KUMON, HIROMI, HUANG, PENG, WATANABE, MASAMI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742810/
https://www.ncbi.nlm.nih.gov/pubmed/23946784
http://dx.doi.org/10.3892/ol.2013.1357
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author LIU, CHUNXIAO
ZHENG, SHAOBO
SHEN, HAIYAN
XU, KAI
CHEN, JIE
LI, HULIN
XU, YAWEN
XU, ABAI
CHEN, BINSHEN
KAKU, HARUKI
NASU, YASUTOMO
KUMON, HIROMI
HUANG, PENG
WATANABE, MASAMI
author_facet LIU, CHUNXIAO
ZHENG, SHAOBO
SHEN, HAIYAN
XU, KAI
CHEN, JIE
LI, HULIN
XU, YAWEN
XU, ABAI
CHEN, BINSHEN
KAKU, HARUKI
NASU, YASUTOMO
KUMON, HIROMI
HUANG, PENG
WATANABE, MASAMI
author_sort LIU, CHUNXIAO
collection PubMed
description Cluster of differentiation (CD)24 was originally described as a B lymphocyte marker and has recently received considerable attention in cancer research as its overexpression has been observed in several types of carcinoma. The CD24 molecule is a glycosyl-phosphatidylinositol-linked cell surface protein that appears to be associated with aggressive cancers involving invasion and metastasis. However, the expression of CD24 in human bladder cancer and its clinical significance remains largely unknown and no association has been reported between CD24 overexpression and human bladder tumor recurrence. In the present study, the CD24 expression in cancer tissues obtained during transurethral surgery and the subsequent intra-bladder tumor recurrence following surgery were assessed. Immunohistochemical staining was performed and the intensity of CD24 staining was semi-quantitatively evaluated. CD24 expression was observed more frequently in high-grade bladder tumors (G2–G3) than low-grade tumors (G1). Positive CD24 expression was significantly associated with intra-bladder tumor recurrence following surgery and increased staining intensity was also correlated with recurrence. The positive association between CD24 expression and tumor recurrence was observed in each tumor category (stages Ta and T1, low and high grade). The results demonstrated that CD24 expression is significantly associated with bladder tumor recurrence. To the best of our knowledge, this is the first study to reveal the significance of CD24 as a predictor of bladder cancer recurrence. These insights may lead to future therapeutic strategies targeting CD24 to prevent the dissemination of bladder cancer cells and tumor recurrence.
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spelling pubmed-37428102013-08-14 Clinical significance of CD24 as a predictor of bladder cancer recurrence LIU, CHUNXIAO ZHENG, SHAOBO SHEN, HAIYAN XU, KAI CHEN, JIE LI, HULIN XU, YAWEN XU, ABAI CHEN, BINSHEN KAKU, HARUKI NASU, YASUTOMO KUMON, HIROMI HUANG, PENG WATANABE, MASAMI Oncol Lett Articles Cluster of differentiation (CD)24 was originally described as a B lymphocyte marker and has recently received considerable attention in cancer research as its overexpression has been observed in several types of carcinoma. The CD24 molecule is a glycosyl-phosphatidylinositol-linked cell surface protein that appears to be associated with aggressive cancers involving invasion and metastasis. However, the expression of CD24 in human bladder cancer and its clinical significance remains largely unknown and no association has been reported between CD24 overexpression and human bladder tumor recurrence. In the present study, the CD24 expression in cancer tissues obtained during transurethral surgery and the subsequent intra-bladder tumor recurrence following surgery were assessed. Immunohistochemical staining was performed and the intensity of CD24 staining was semi-quantitatively evaluated. CD24 expression was observed more frequently in high-grade bladder tumors (G2–G3) than low-grade tumors (G1). Positive CD24 expression was significantly associated with intra-bladder tumor recurrence following surgery and increased staining intensity was also correlated with recurrence. The positive association between CD24 expression and tumor recurrence was observed in each tumor category (stages Ta and T1, low and high grade). The results demonstrated that CD24 expression is significantly associated with bladder tumor recurrence. To the best of our knowledge, this is the first study to reveal the significance of CD24 as a predictor of bladder cancer recurrence. These insights may lead to future therapeutic strategies targeting CD24 to prevent the dissemination of bladder cancer cells and tumor recurrence. D.A. Spandidos 2013-07 2013-05-21 /pmc/articles/PMC3742810/ /pubmed/23946784 http://dx.doi.org/10.3892/ol.2013.1357 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
LIU, CHUNXIAO
ZHENG, SHAOBO
SHEN, HAIYAN
XU, KAI
CHEN, JIE
LI, HULIN
XU, YAWEN
XU, ABAI
CHEN, BINSHEN
KAKU, HARUKI
NASU, YASUTOMO
KUMON, HIROMI
HUANG, PENG
WATANABE, MASAMI
Clinical significance of CD24 as a predictor of bladder cancer recurrence
title Clinical significance of CD24 as a predictor of bladder cancer recurrence
title_full Clinical significance of CD24 as a predictor of bladder cancer recurrence
title_fullStr Clinical significance of CD24 as a predictor of bladder cancer recurrence
title_full_unstemmed Clinical significance of CD24 as a predictor of bladder cancer recurrence
title_short Clinical significance of CD24 as a predictor of bladder cancer recurrence
title_sort clinical significance of cd24 as a predictor of bladder cancer recurrence
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742810/
https://www.ncbi.nlm.nih.gov/pubmed/23946784
http://dx.doi.org/10.3892/ol.2013.1357
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