Cargando…
Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas
The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O(6)-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors wer...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742817/ https://www.ncbi.nlm.nih.gov/pubmed/23946790 http://dx.doi.org/10.3892/ol.2013.1317 |
_version_ | 1782280419285139456 |
---|---|
author | HU, XINHUA MIAO, WEI ZOU, YUANJIE ZHANG, WENBIN ZHANG, YANSONG LIU, HONGYI |
author_facet | HU, XINHUA MIAO, WEI ZOU, YUANJIE ZHANG, WENBIN ZHANG, YANSONG LIU, HONGYI |
author_sort | HU, XINHUA |
collection | PubMed |
description | The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O(6)-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified according to the recommendations of the World Health Organization (WHO; 2007) into grade I (n=9), grade II (n=56), grade III (n=52) and grade IV (n=35). The expression of p53, Ki-67, EGFR and MGMT was analyzed using immunohistochemistry. The frequency of p53 immunopositivity was significantly lower in grade I gliomas than in grades II, III and IV. The frequency of EGFR immunopositivity was significantly higher in grade III and IV gliomas compared with grades I and II. The mean Ki-67 labelling index (LI) significantly increased in the higher glioma grades. The expression of MGMT in grade I and II tumors was not significantly different from that of grade III and IV tumors. The present data indicate that the expression of EGFR and Ki-67 is significantly correlated with the histological grade of the glioma, but that the expression of p53 and MGMT is not associated with the tumor grade. |
format | Online Article Text |
id | pubmed-3742817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37428172013-08-14 Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas HU, XINHUA MIAO, WEI ZOU, YUANJIE ZHANG, WENBIN ZHANG, YANSONG LIU, HONGYI Oncol Lett Articles The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O(6)-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified according to the recommendations of the World Health Organization (WHO; 2007) into grade I (n=9), grade II (n=56), grade III (n=52) and grade IV (n=35). The expression of p53, Ki-67, EGFR and MGMT was analyzed using immunohistochemistry. The frequency of p53 immunopositivity was significantly lower in grade I gliomas than in grades II, III and IV. The frequency of EGFR immunopositivity was significantly higher in grade III and IV gliomas compared with grades I and II. The mean Ki-67 labelling index (LI) significantly increased in the higher glioma grades. The expression of MGMT in grade I and II tumors was not significantly different from that of grade III and IV tumors. The present data indicate that the expression of EGFR and Ki-67 is significantly correlated with the histological grade of the glioma, but that the expression of p53 and MGMT is not associated with the tumor grade. D.A. Spandidos 2013-07 2013-04-24 /pmc/articles/PMC3742817/ /pubmed/23946790 http://dx.doi.org/10.3892/ol.2013.1317 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles HU, XINHUA MIAO, WEI ZOU, YUANJIE ZHANG, WENBIN ZHANG, YANSONG LIU, HONGYI Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title | Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title_full | Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title_fullStr | Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title_full_unstemmed | Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title_short | Expression of p53, epidermal growth factor receptor, Ki-67 and O(6)-methylguanine-DNA methyltransferase in human gliomas |
title_sort | expression of p53, epidermal growth factor receptor, ki-67 and o(6)-methylguanine-dna methyltransferase in human gliomas |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742817/ https://www.ncbi.nlm.nih.gov/pubmed/23946790 http://dx.doi.org/10.3892/ol.2013.1317 |
work_keys_str_mv | AT huxinhua expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas AT miaowei expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas AT zouyuanjie expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas AT zhangwenbin expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas AT zhangyansong expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas AT liuhongyi expressionofp53epidermalgrowthfactorreceptorki67ando6methylguaninednamethyltransferaseinhumangliomas |