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To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells

Mesenchymal stem or stromal cells (MSCs) are precursor cells that play important roles in tumorigenesis. MSCs are recruited to tumors from local and distant sources to form part of the tumor microenvironment. MSCs influence tumor progression by interacting with cancer cells, endothelial cells, immun...

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Detalles Bibliográficos
Autores principales: Droujinine, Ilia A., Eckert, Mark A., Zhao, Weian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742827/
https://www.ncbi.nlm.nih.gov/pubmed/23744479
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author Droujinine, Ilia A.
Eckert, Mark A.
Zhao, Weian
author_facet Droujinine, Ilia A.
Eckert, Mark A.
Zhao, Weian
author_sort Droujinine, Ilia A.
collection PubMed
description Mesenchymal stem or stromal cells (MSCs) are precursor cells that play important roles in tumorigenesis. MSCs are recruited to tumors from local and distant sources to form part of the tumor microenvironment. MSCs influence tumor progression by interacting with cancer cells, endothelial cells, immune cells, and cancer stem cells, in a context-dependent network. This review aims to synthesize this emerging yet controversial field to identify key questions regarding the mechanisms of MSC mobilization and survival in blood; homing to tumors, metastases, and premetastatic sites; spatiotemporal organization and differentiation; and interaction with immune cells and cancer stem cells. Understanding the fundamental biology underlying mesenchymal stem cell and tumor interactions has the potential to inform our knowledge of cancer initiation and progression as well as lead to novel therapeutics for cancer. Furthermore, knowledge of endogenous mechanisms can be used to “program” exogenous MSCs for targeted chemotherapeutic delivery to tumors and metastases. Emerging studies will provide crucial insight into the mechanisms of tumor interactions with the whole organism including MSCs.
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spelling pubmed-37428272013-08-15 To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells Droujinine, Ilia A. Eckert, Mark A. Zhao, Weian Oncotarget Reviews Mesenchymal stem or stromal cells (MSCs) are precursor cells that play important roles in tumorigenesis. MSCs are recruited to tumors from local and distant sources to form part of the tumor microenvironment. MSCs influence tumor progression by interacting with cancer cells, endothelial cells, immune cells, and cancer stem cells, in a context-dependent network. This review aims to synthesize this emerging yet controversial field to identify key questions regarding the mechanisms of MSC mobilization and survival in blood; homing to tumors, metastases, and premetastatic sites; spatiotemporal organization and differentiation; and interaction with immune cells and cancer stem cells. Understanding the fundamental biology underlying mesenchymal stem cell and tumor interactions has the potential to inform our knowledge of cancer initiation and progression as well as lead to novel therapeutics for cancer. Furthermore, knowledge of endogenous mechanisms can be used to “program” exogenous MSCs for targeted chemotherapeutic delivery to tumors and metastases. Emerging studies will provide crucial insight into the mechanisms of tumor interactions with the whole organism including MSCs. Impact Journals LLC 2013-05-31 /pmc/articles/PMC3742827/ /pubmed/23744479 Text en Copyright: © 2013 Droujinine et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Reviews
Droujinine, Ilia A.
Eckert, Mark A.
Zhao, Weian
To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title_full To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title_fullStr To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title_full_unstemmed To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title_short To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells
title_sort to grab the stroma by the horns: from biology to cancer therapy with mesenchymal stem cells
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742827/
https://www.ncbi.nlm.nih.gov/pubmed/23744479
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