FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies

Therapies targeting MAPK and AKT/mTOR signaling are currently being evaluated in clinical trials for several tumor types. However, recent studies suggest that these therapies may be limited due to acquired cancer cell resistance and a small therapeutic index between normal and cancer cells. The iden...

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Detalles Bibliográficos
Autores principales: Cipriano, Rocky, Miskimen, Kristy L.S., Bryson, Benjamin L., Foy, Chase R., Bartel, Courtney A., Jackson, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742833/
https://www.ncbi.nlm.nih.gov/pubmed/23676467

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