A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

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In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies. In a model for p185(BCR-ABL+) B-acute lymphoid leukemia, we show that CDK6 is part of a transcription complex that induces the expression of the tumor suppressor p16(INK4a) and the...

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Detalles Bibliográficos
Autores principales: Kollmann, Karoline, Heller, Gerwin, Schneckenleithner, Christine, Warsch, Wolfgang, Scheicher, Ruth, Ott, Rene G., Schäfer, Markus, Fajmann, Sabine, Schlederer, Michaela, Schiefer, Ana-Iris, Reichart, Ursula, Mayerhofer, Matthias, Hoeller, Christoph, Zöchbauer-Müller, Sabine, Kerjaschki, Dontscho, Bock, Christoph, Kenner, Lukas, Hoefler, Gerald, Freissmuth, Michael, Green, Anthony R., Moriggl, Richard, Busslinger, Meinrad, Malumbres, Marcos, Sexl, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743049/
https://www.ncbi.nlm.nih.gov/pubmed/23948297
http://dx.doi.org/10.1016/j.ccr.2013.07.012
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