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Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel Na(V)1.6 by Calmodulin

The neuronal-voltage gated sodium channel (VGSC), Na(V)1.6, plays an important role in propagating action potentials along myelinated axons. Calmodulin (CaM) is known to modulate the inactivation kinetics of Na(V)1.6 by interacting with its IQ motif. Here we report the crystal structure of apo-CaM:N...

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Detalles Bibliográficos
Autores principales:	Chichili, Vishnu Priyanka Reddy, Xiao, Yucheng, Seetharaman, J., Cummins, Theodore R., Sivaraman, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743062/ https://www.ncbi.nlm.nih.gov/pubmed/23942337 http://dx.doi.org/10.1038/srep02435

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