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Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer

PURPOSE: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS AND METHODS: The medical records of breast cancer patients who were treated and followed at Ga...

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Autores principales: Ahn, Sung Gwe, Lee, Hak Min, Cho, Sang-Hoon, Lee, Seung Ah, Hwang, Seung Hyun, Jeong, Joon, Lee, Hy-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743183/
https://www.ncbi.nlm.nih.gov/pubmed/23918566
http://dx.doi.org/10.3349/ymj.2013.54.5.1168
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author Ahn, Sung Gwe
Lee, Hak Min
Cho, Sang-Hoon
Lee, Seung Ah
Hwang, Seung Hyun
Jeong, Joon
Lee, Hy-De
author_facet Ahn, Sung Gwe
Lee, Hak Min
Cho, Sang-Hoon
Lee, Seung Ah
Hwang, Seung Hyun
Jeong, Joon
Lee, Hy-De
author_sort Ahn, Sung Gwe
collection PubMed
description PURPOSE: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS AND METHODS: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. RESULTS: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18; 95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor. CONCLUSION: Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation.
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spelling pubmed-37431832013-09-01 Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer Ahn, Sung Gwe Lee, Hak Min Cho, Sang-Hoon Lee, Seung Ah Hwang, Seung Hyun Jeong, Joon Lee, Hy-De Yonsei Med J Original Article PURPOSE: Bone is the most frequent site of metastasis among breast cancer patients. We investigated prognostic factors affecting survival following bone-only metastasis in breast cancer patients. MATERIALS AND METHODS: The medical records of breast cancer patients who were treated and followed at Gangnam Severance Hospital retrospectively reviewed to identify patients with bone-only metastasis. RESULTS: The median time from the diagnosis of bone-only metastasis to the last follow-up or death was 55.2 [95% confidence interval (CI), 38.6-71.9] months. The Kaplan-Meier overall survival estimate at 10 years for all patients was 34.9%. In the multivariate Cox regression model, bisphosphonate treatment [hazard ratio=0.18; 95% CI, 0.07-0.43], estrogen receptor positivity (hazard ratio=0.51; 95% CI, 0.28-0.94), and solitary bone metastasis (hazard ratio=0.32; 95% CI, 0.14-0.72) were significantly associated with longer overall survival in the bone-only recurrence group. Among the treatment modalities, only bisphosphonate treatment was identified as a significant prognostic factor. CONCLUSION: Identifying the factors influencing breast cancer mortality after bone-only metastasis will help clarify the clinical course and improve the treatment outcome for patients with breast cancer and bone-only metastasis. Bisphosphonates, as a significant prognostic factor, warrant further investigation. Yonsei University College of Medicine 2013-09-01 2013-07-23 /pmc/articles/PMC3743183/ /pubmed/23918566 http://dx.doi.org/10.3349/ymj.2013.54.5.1168 Text en © Copyright: Yonsei University College of Medicine 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ahn, Sung Gwe
Lee, Hak Min
Cho, Sang-Hoon
Lee, Seung Ah
Hwang, Seung Hyun
Jeong, Joon
Lee, Hy-De
Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title_full Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title_fullStr Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title_full_unstemmed Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title_short Prognostic Factors for Patients with Bone-Only Metastasis in Breast Cancer
title_sort prognostic factors for patients with bone-only metastasis in breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743183/
https://www.ncbi.nlm.nih.gov/pubmed/23918566
http://dx.doi.org/10.3349/ymj.2013.54.5.1168
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