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Association between serum biochemical levels, related to bone metabolism and Parkinson's disease

BACKGROUND: Vitamin D insufficiency and serum calcium disturbance have been reported to be more common in Parkinson's disease (PD) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. Because of the hi...

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Autores principales: Meamar, Rokhsareh, Maracy, Mohammad, Chitsaz, Ahmad, Ghazvini, Mohammad Reza Aghaye, Izadi, Maryam, Tanhaei, Amir Pouya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743317/
https://www.ncbi.nlm.nih.gov/pubmed/23961283
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author Meamar, Rokhsareh
Maracy, Mohammad
Chitsaz, Ahmad
Ghazvini, Mohammad Reza Aghaye
Izadi, Maryam
Tanhaei, Amir Pouya
author_facet Meamar, Rokhsareh
Maracy, Mohammad
Chitsaz, Ahmad
Ghazvini, Mohammad Reza Aghaye
Izadi, Maryam
Tanhaei, Amir Pouya
author_sort Meamar, Rokhsareh
collection PubMed
description BACKGROUND: Vitamin D insufficiency and serum calcium disturbance have been reported to be more common in Parkinson's disease (PD) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. Because of the high-vitamin D insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in PD patients in comparison with age-matched healthy controls, for the 1(st) time in a Middle East population. MATERIALS AND METHODS: This case-control study was involved 105 (20 were excluded) PD patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin D (25OHD) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods. RESULTS: There was no significant difference in 25OHD between PD patients and control group (P = 0.071). 25OHD level was not significantly different in PD patients compared to controls {odds ratio 1.003, (confidence interval [CI], 0.98-1.02), P value 0.793}. None of the other biochemical levels did not induce more chance for PD, only we observed in men has more risk of PD than women (odds ratio 2.53, [CI, 1.27-5.03], P value 0.008). CONCLUSION: Our data do not support a possible role of vitamin D insufficiency in PD. Regarding to variable changes in biochemical markers in PD patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of PD.
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spelling pubmed-37433172013-08-19 Association between serum biochemical levels, related to bone metabolism and Parkinson's disease Meamar, Rokhsareh Maracy, Mohammad Chitsaz, Ahmad Ghazvini, Mohammad Reza Aghaye Izadi, Maryam Tanhaei, Amir Pouya J Res Med Sci Original Article BACKGROUND: Vitamin D insufficiency and serum calcium disturbance have been reported to be more common in Parkinson's disease (PD) patients than in healthy control subjects, which may be due to a chronic disease or reduced mobility contributes to these relatively disturbances. Because of the high-vitamin D insufficiency in our population, we aimed to compare a biochemical levels which are related to bone metabolism, in PD patients in comparison with age-matched healthy controls, for the 1(st) time in a Middle East population. MATERIALS AND METHODS: This case-control study was involved 105 (20 were excluded) PD patients, who were age- and -sex matched with 112 controls. 25-hydroxyvitamin D (25OHD) and parathyroid hormone analyzed by enzyme immunoassay; another laboratory data including, calcium, phosphorous, and alkaline phosphatase were performed by spectrophotometric methods. RESULTS: There was no significant difference in 25OHD between PD patients and control group (P = 0.071). 25OHD level was not significantly different in PD patients compared to controls {odds ratio 1.003, (confidence interval [CI], 0.98-1.02), P value 0.793}. None of the other biochemical levels did not induce more chance for PD, only we observed in men has more risk of PD than women (odds ratio 2.53, [CI, 1.27-5.03], P value 0.008). CONCLUSION: Our data do not support a possible role of vitamin D insufficiency in PD. Regarding to variable changes in biochemical markers in PD patients than in controls; further studies are suggested to determine any plausibility role of them as a causal relationship or as an outcome of PD. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3743317/ /pubmed/23961283 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Meamar, Rokhsareh
Maracy, Mohammad
Chitsaz, Ahmad
Ghazvini, Mohammad Reza Aghaye
Izadi, Maryam
Tanhaei, Amir Pouya
Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title_full Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title_fullStr Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title_full_unstemmed Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title_short Association between serum biochemical levels, related to bone metabolism and Parkinson's disease
title_sort association between serum biochemical levels, related to bone metabolism and parkinson's disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743317/
https://www.ncbi.nlm.nih.gov/pubmed/23961283
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