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Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study

BACKGROUND: Circadian rhythm sleep disorders are a presentation of sleep disorders in patients with multiple sclerosis (MS). This study aims to compare this problem in MS patients with healthy people and to determine its association with chronic fatigue in MS patients. MATERIALS AND METHODS: A case-...

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Autores principales: Najafi, Mohammad Reza, Toghianifar, Nafiseh, Etemadifar, Masoud, Haghighi, Sepehr, Maghzi, Amir Hadi, Akbari, Mojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743326/
https://www.ncbi.nlm.nih.gov/pubmed/23961292
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author Najafi, Mohammad Reza
Toghianifar, Nafiseh
Etemadifar, Masoud
Haghighi, Sepehr
Maghzi, Amir Hadi
Akbari, Mojtaba
author_facet Najafi, Mohammad Reza
Toghianifar, Nafiseh
Etemadifar, Masoud
Haghighi, Sepehr
Maghzi, Amir Hadi
Akbari, Mojtaba
author_sort Najafi, Mohammad Reza
collection PubMed
description BACKGROUND: Circadian rhythm sleep disorders are a presentation of sleep disorders in patients with multiple sclerosis (MS). This study aims to compare this problem in MS patients with healthy people and to determine its association with chronic fatigue in MS patients. MATERIALS AND METHODS: A case-control study was performed on 120 MS patients and 60 healthy subjects matched for age and sex, in 2009 in MS Clinic Alzahra Hospital. Sleep quality, rhythm and fatigue severity were assessed using PSQI (Pittsburgh sleep quality index) and FSS (Fatigue severity Scale) questionnaires, respectively. Its reliability and validity has been confirmed in several studies (Cronbach's alpha = 0.83). This index has seven sections including patient's assessment of his/her sleep, sleep duration, efficacy of routine sleep, sleep disorders, use of hypnotic medication, and dysfunction in daily activities. RESULTS: Circadian rhythm sleep disorder was more frequent in MS patients relative to healthy subjects (P: 0.002). It was higher in MS patients with severe fatigue relative to MS patients with mild fatigue (P: 0.05). Fatigue severity was 49.9 ± 8.2 and 22.5 ± 7.4 in the first and second group, respectively. PSQI index was 7.9 ± 4.5 in patients with severe fatigue and 5.9 ± 4.5 in patients with mild fatigue and 4.5 ± 2.4 in the control group (P: 0.0001). CONCLUSION: Circadian rhythm sleep disorders are more frequent in MS patients and those with fatigue. Recognition and management of circadian rhythm sleep disorders in MS patients, especially those with fatigue may be helpful in improving care of these patients.
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spelling pubmed-37433262013-08-19 Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study Najafi, Mohammad Reza Toghianifar, Nafiseh Etemadifar, Masoud Haghighi, Sepehr Maghzi, Amir Hadi Akbari, Mojtaba J Res Med Sci Original Article BACKGROUND: Circadian rhythm sleep disorders are a presentation of sleep disorders in patients with multiple sclerosis (MS). This study aims to compare this problem in MS patients with healthy people and to determine its association with chronic fatigue in MS patients. MATERIALS AND METHODS: A case-control study was performed on 120 MS patients and 60 healthy subjects matched for age and sex, in 2009 in MS Clinic Alzahra Hospital. Sleep quality, rhythm and fatigue severity were assessed using PSQI (Pittsburgh sleep quality index) and FSS (Fatigue severity Scale) questionnaires, respectively. Its reliability and validity has been confirmed in several studies (Cronbach's alpha = 0.83). This index has seven sections including patient's assessment of his/her sleep, sleep duration, efficacy of routine sleep, sleep disorders, use of hypnotic medication, and dysfunction in daily activities. RESULTS: Circadian rhythm sleep disorder was more frequent in MS patients relative to healthy subjects (P: 0.002). It was higher in MS patients with severe fatigue relative to MS patients with mild fatigue (P: 0.05). Fatigue severity was 49.9 ± 8.2 and 22.5 ± 7.4 in the first and second group, respectively. PSQI index was 7.9 ± 4.5 in patients with severe fatigue and 5.9 ± 4.5 in patients with mild fatigue and 4.5 ± 2.4 in the control group (P: 0.0001). CONCLUSION: Circadian rhythm sleep disorders are more frequent in MS patients and those with fatigue. Recognition and management of circadian rhythm sleep disorders in MS patients, especially those with fatigue may be helpful in improving care of these patients. Medknow Publications & Media Pvt Ltd 2013-03 /pmc/articles/PMC3743326/ /pubmed/23961292 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Najafi, Mohammad Reza
Toghianifar, Nafiseh
Etemadifar, Masoud
Haghighi, Sepehr
Maghzi, Amir Hadi
Akbari, Mojtaba
Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title_full Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title_fullStr Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title_full_unstemmed Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title_short Circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: A case-control study
title_sort circadian rhythm sleep disorders in patients with multiple sclerosis and its association with fatigue: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743326/
https://www.ncbi.nlm.nih.gov/pubmed/23961292
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