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Leflunomide Reduces Proliferation and Induces Apoptosis in Neuroblastoma Cells In Vitro and In Vivo

Leflunomide as an immunosuppressive drug is generally used in the treatment of rheumatoid arthritis. It inhibits DHODH (dihydroorotate dehydrogenase ), which is one of the essential enzymes in the de novo pyrimidine biosynthetic pathway. Here we showed that leflunomide significantly reduced cell pro...

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Detalles Bibliográficos
Autores principales:	Zhu, Shunqin, Yan, Xiaomin, Xiang, Zhonghuai, Ding, Han-Fei, Cui, Hongjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743402/ https://www.ncbi.nlm.nih.gov/pubmed/23977077 http://dx.doi.org/10.1371/journal.pone.0071555

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