Cargando…

Leflunomide Reduces Proliferation and Induces Apoptosis in Neuroblastoma Cells In Vitro and In Vivo

Leflunomide as an immunosuppressive drug is generally used in the treatment of rheumatoid arthritis. It inhibits DHODH (dihydroorotate dehydrogenase ), which is one of the essential enzymes in the de novo pyrimidine biosynthetic pathway. Here we showed that leflunomide significantly reduced cell pro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Shunqin, Yan, Xiaomin, Xiang, Zhonghuai, Ding, Han-Fei, Cui, Hongjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743402/ https://www.ncbi.nlm.nih.gov/pubmed/23977077 http://dx.doi.org/10.1371/journal.pone.0071555

Ejemplares similares

Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells
por: Ke, Xiao-Xue, et al.
Publicado: (2014)

Correction: Inhibition of H3K9 Methyltransferase G9a Repressed Cell Proliferation and Induced Autophagy in Neuroblastoma Cells
por: Ke, Xiao-Xue, et al.
Publicado: (2019)

Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation
por: Li, Jifu, et al.
Publicado: (2019)

Down-regulation of CHERP inhibits neuroblastoma cell proliferation and induces apoptosis through ER stress induction
por: Zhang, Dunke, et al.
Publicado: (2017)

Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells
por: YAN, XIAOMIN, et al.
Publicado: (2015)

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma
por: Yu, Yajie, et al.
Publicado: (2021)

BMP4 and Neuregulin regulate the direction of mouse neural crest cell differentiation
por: Zhu, Shunqin, et al.
Publicado: (2019)

Effectiveness and safety of leflunomide compared with cyclophosphamide as induction therapy in Takayasu’s arteritis: an observational study
por: Dai, Xiaomin, et al.
Publicado: (2020)

Leflunomide-Induced Hidradenitis Suppurativa
por: Machan, Achraf, et al.
Publicado: (2020)

Leflunomide inhibits the apoptosis of human embryonic lung fibroblasts infected by human cytomegalovirus
por: Qi, Ren, et al.
Publicado: (2013)

Interleukin-18 in Brazilian Rheumatoid Arthritis Patients: Can Leflunomide Reduce It?
por: Gualberto Cardoso, Pablo Ramon, et al.
Publicado: (2021)

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
por: Yang, Liqun, et al.
Publicado: (2019)

TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway
por: Gu, Hongyu, et al.
Publicado: (2022)

Leflunomide leads to inhibition of transendothelial migration
por: Grisar, J, et al.
Publicado: (2001)

Amelioration of Experimental Autoimmune Uveitis by Leflunomide in Lewis Rats
por: Fang, Cheng-bo, et al.
Publicado: (2013)

Runt-related transcription factor 1 promotes apoptosis and inhibits neuroblastoma progression in vitro and in vivo
por: Hong, Mei, et al.
Publicado: (2020)

Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells
por: Cheng, Li, et al.
Publicado: (2020)

Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma
por: Dong, Zhen, et al.
Publicado: (2017)

Role of several histone lysine methyltransferases in tumor development
por: LI, JIFU, et al.
Publicado: (2016)

Efficacy and safety of leflunomide versus cyclophosphamide for initial-onset Takayasu arteritis: a prospective cohort study
por: Ying, Sun, et al.
Publicado: (2020)

The effect of tubeimoside-1 on the proliferation, metastasis and apoptosis of oral squamous cell carcinoma in vitro
por: Wu, Tingting, et al.
Publicado: (2018)

Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cells
por: PENG, HONGWEI, et al.
Publicado: (2015)

Synergy and Mechanism of Leflunomide Plus Fluconazole Against Resistant Candida albicans: An in vitro Study
por: Li, Xiuyun, et al.
Publicado: (2023)

Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β
por: Wang, Mei, et al.
Publicado: (2015)

Genome-wide analysis of HOXC9-induced neuronal differentiation of neuroblastoma cells()
por: Wang, Xiangwei, et al.
Publicado: (2014)

Use of leflunomide in patients with chronic hypersensitivity pneumonitis
por: Noh, Sungryong, et al.
Publicado: (2020)

8. Myositis as an idiosyncratic drug reaction to leflunomide
por: Darren, Angeline, et al.
Publicado: (2019)

Efficacy and Safety of Leflunomide for Refractory COVID-19: A Pilot Study
por: Wang, Qiang, et al.
Publicado: (2021)

Effectiveness and safety of methotrexate versus leflunomide in 12-month treatment for Takayasu arteritis
por: Wu, Chunling, et al.
Publicado: (2020)

Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression
por: Mao, Ling, et al.
Publicado: (2011)

Knockdown of arsenic resistance protein 2 inhibits human glioblastoma cell proliferation through the MAPK/ERK pathway
por: Ke, Xiao-Xue, et al.
Publicado: (2018)

Mitomycin, 5-fluorouracil, leflunomide, and mycophenolic acid directly promote hepatitis B virus replication and expression in vitro
por: Ruan, Jie, et al.
Publicado: (2020)

Ginsenoside Compound K Induces Ros-Mediated Apoptosis and Autophagic Inhibition in Human Neuroblastoma Cells In Vitro and In Vivo
por: Oh, Jung-Mi, et al.
Publicado: (2019)

EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth
por: Bownes, Laura V., et al.
Publicado: (2021)

Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro
por: Chen, Jiajun, et al.
Publicado: (2018)

Functional Dissection of HOXD Cluster Genes in Regulation of Neuroblastoma Cell Proliferation and Differentiation
por: Zha, Yunhong, et al.
Publicado: (2012)

Differential effects of leflunomide and methotrexate on cytokine production in RA
por: Kraan, MC, et al.
Publicado: (2003)

Formation of multiple pulmonary nodules during treatment with leflunomide
por: Yoshikawa, Gilberto Toshikawa, et al.
Publicado: (2015)

A Retrospective Study on the Safety and Efficacy of Leflunomide in Dogs
por: Sato, M., et al.
Publicado: (2017)

Leflunomide for BKvirus: Report of Seven Kidney-Transplanted Children
por: Launay, M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_g5cktt4qi22qh3ku36bkjv5ove