Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)

The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblast...

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Detalles Bibliográficos
Autores principales: Carlson, Andrew P., Yonas, Howard, Olson, Garth T., Reichard, Kaaren K., Medina-Flores, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743586/
https://www.ncbi.nlm.nih.gov/pubmed/23984205
http://dx.doi.org/10.1055/s-0031-1275638
Descripción
Sumario:The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.

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