Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)

The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblast...

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Detalles Bibliográficos
Autores principales: Carlson, Andrew P., Yonas, Howard, Olson, Garth T., Reichard, Kaaren K., Medina-Flores, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743586/
https://www.ncbi.nlm.nih.gov/pubmed/23984205
http://dx.doi.org/10.1055/s-0031-1275638
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author Carlson, Andrew P.
Yonas, Howard
Olson, Garth T.
Reichard, Kaaren K.
Medina-Flores, Rafael
author_facet Carlson, Andrew P.
Yonas, Howard
Olson, Garth T.
Reichard, Kaaren K.
Medina-Flores, Rafael
author_sort Carlson, Andrew P.
collection PubMed
description The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined.
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spelling pubmed-37435862013-08-27 Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13) Carlson, Andrew P. Yonas, Howard Olson, Garth T. Reichard, Kaaren K. Medina-Flores, Rafael Skull Base Rep Article The case of a 51-year-old man with a large temporal mass is presented. The mass eroded the floor of the middle fossa medially to the sphenoid sinus. A combined approach with neurosurgery and otolaryngology was performed to achieve maximal resection of the mass. Pathology was typical for chondroblastoma: a rare, benign but locally invasive chondroid tumor. Genetic testing revealed a translocation of (2;5) (q33;q13). This is a unique genetic mutation in all chondroid tumors to our knowledge. The diagnostic utility or role of this mutation in the pathobiology of this tumor remains to be determined. Thieme Medical Publishers 2011-03-25 2011-05 /pmc/articles/PMC3743586/ /pubmed/23984205 http://dx.doi.org/10.1055/s-0031-1275638 Text en © Thieme Medical Publishers
spellingShingle Article
Carlson, Andrew P.
Yonas, Howard
Olson, Garth T.
Reichard, Kaaren K.
Medina-Flores, Rafael
Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title_full Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title_fullStr Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title_full_unstemmed Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title_short Temporal Chondroblastoma with a Novel Chromosomal Translocation (2;5) (q33;q13)
title_sort temporal chondroblastoma with a novel chromosomal translocation (2;5) (q33;q13)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743586/
https://www.ncbi.nlm.nih.gov/pubmed/23984205
http://dx.doi.org/10.1055/s-0031-1275638
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AT reichardkaarenk temporalchondroblastomawithanovelchromosomaltranslocation25q33q13
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