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IGF-1-Induced Enhancement of PRNP Expression Depends on the Negative Regulation of Transcription Factor FOXO3a

The conformational conversion of the cellular prion protein (PrP(C)) into its β-sheet-rich scrapie isoform (PrP(Sc)) causes fatal prion diseases, which are also called transmissible spongiform encephalopathies (TSEs). Recent studies suggest that the expression of PrP(C) by the PRNP gene is crucial f...

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Detalles Bibliográficos
Autores principales:	Liu, Ting, Yi, Wenjing, Feng, Boya, Zhou, Zheng, Xiao, Gengfu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743769/ https://www.ncbi.nlm.nih.gov/pubmed/23967259 http://dx.doi.org/10.1371/journal.pone.0071896

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