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Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells
The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival. Disruption of HOX protein function using the peptide HXR9 has shown anti-tumor effects against melanoma, lung cancer, and renal cance...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743965/ https://www.ncbi.nlm.nih.gov/pubmed/20574452 http://dx.doi.org/10.1038/leu.2010.142 |