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The septum transversum mesenchyme induces gall bladder development
The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744069/ https://www.ncbi.nlm.nih.gov/pubmed/23951403 http://dx.doi.org/10.1242/bio.20135348 |
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author | Saito, Yohei Kojima, Takuya Takahashi, Naoki |
author_facet | Saito, Yohei Kojima, Takuya Takahashi, Naoki |
author_sort | Saito, Yohei |
collection | PubMed |
description | The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the cell-extrinsic signals that regulate this differentiation process are unknown. This study shows that the septum transversum mesenchyme (STM) grows in the posterior direction after E8.5, becoming adjacent to the presumptive gall bladder region, to induce gall bladder development. In this induction process, STM-derived BMP4 induces differentiation from common progenitor cells adjacent to the STM into gall bladder progenitor cells, by maintaining Sox17 expression and suppressing Pdx1 expression. Furthermore, the STM suppresses ectopic activation of the liver program in the posterior region of the ventral foregut following hepatic induction through an Fgf10/Fgfr2b/Sox9 signaling pathway. Thus, the STM plays pivotal roles in gall bladder development by both inductive and suppressive effects. |
format | Online Article Text |
id | pubmed-3744069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Company of Biologists |
record_format | MEDLINE/PubMed |
spelling | pubmed-37440692013-08-15 The septum transversum mesenchyme induces gall bladder development Saito, Yohei Kojima, Takuya Takahashi, Naoki Biol Open Research Article The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the cell-extrinsic signals that regulate this differentiation process are unknown. This study shows that the septum transversum mesenchyme (STM) grows in the posterior direction after E8.5, becoming adjacent to the presumptive gall bladder region, to induce gall bladder development. In this induction process, STM-derived BMP4 induces differentiation from common progenitor cells adjacent to the STM into gall bladder progenitor cells, by maintaining Sox17 expression and suppressing Pdx1 expression. Furthermore, the STM suppresses ectopic activation of the liver program in the posterior region of the ventral foregut following hepatic induction through an Fgf10/Fgfr2b/Sox9 signaling pathway. Thus, the STM plays pivotal roles in gall bladder development by both inductive and suppressive effects. The Company of Biologists 2013-06-20 /pmc/articles/PMC3744069/ /pubmed/23951403 http://dx.doi.org/10.1242/bio.20135348 Text en © 2013. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Research Article Saito, Yohei Kojima, Takuya Takahashi, Naoki The septum transversum mesenchyme induces gall bladder development |
title | The septum transversum mesenchyme induces gall bladder development |
title_full | The septum transversum mesenchyme induces gall bladder development |
title_fullStr | The septum transversum mesenchyme induces gall bladder development |
title_full_unstemmed | The septum transversum mesenchyme induces gall bladder development |
title_short | The septum transversum mesenchyme induces gall bladder development |
title_sort | septum transversum mesenchyme induces gall bladder development |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744069/ https://www.ncbi.nlm.nih.gov/pubmed/23951403 http://dx.doi.org/10.1242/bio.20135348 |
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