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The septum transversum mesenchyme induces gall bladder development

The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the...

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Detalles Bibliográficos
Autores principales: Saito, Yohei, Kojima, Takuya, Takahashi, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744069/
https://www.ncbi.nlm.nih.gov/pubmed/23951403
http://dx.doi.org/10.1242/bio.20135348
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author Saito, Yohei
Kojima, Takuya
Takahashi, Naoki
author_facet Saito, Yohei
Kojima, Takuya
Takahashi, Naoki
author_sort Saito, Yohei
collection PubMed
description The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the cell-extrinsic signals that regulate this differentiation process are unknown. This study shows that the septum transversum mesenchyme (STM) grows in the posterior direction after E8.5, becoming adjacent to the presumptive gall bladder region, to induce gall bladder development. In this induction process, STM-derived BMP4 induces differentiation from common progenitor cells adjacent to the STM into gall bladder progenitor cells, by maintaining Sox17 expression and suppressing Pdx1 expression. Furthermore, the STM suppresses ectopic activation of the liver program in the posterior region of the ventral foregut following hepatic induction through an Fgf10/Fgfr2b/Sox9 signaling pathway. Thus, the STM plays pivotal roles in gall bladder development by both inductive and suppressive effects.
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spelling pubmed-37440692013-08-15 The septum transversum mesenchyme induces gall bladder development Saito, Yohei Kojima, Takuya Takahashi, Naoki Biol Open Research Article The liver, gall bladder, and ventral pancreas are formed from the posterior region of the ventral foregut. After hepatic induction, Sox17+/Pdx1+ pancreatobiliary common progenitor cells differentiate into Sox17+/Pdx1− gall bladder progenitors and Sox17−/Pdx1+ ventral pancreatic progenitors, but the cell-extrinsic signals that regulate this differentiation process are unknown. This study shows that the septum transversum mesenchyme (STM) grows in the posterior direction after E8.5, becoming adjacent to the presumptive gall bladder region, to induce gall bladder development. In this induction process, STM-derived BMP4 induces differentiation from common progenitor cells adjacent to the STM into gall bladder progenitor cells, by maintaining Sox17 expression and suppressing Pdx1 expression. Furthermore, the STM suppresses ectopic activation of the liver program in the posterior region of the ventral foregut following hepatic induction through an Fgf10/Fgfr2b/Sox9 signaling pathway. Thus, the STM plays pivotal roles in gall bladder development by both inductive and suppressive effects. The Company of Biologists 2013-06-20 /pmc/articles/PMC3744069/ /pubmed/23951403 http://dx.doi.org/10.1242/bio.20135348 Text en © 2013. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
Saito, Yohei
Kojima, Takuya
Takahashi, Naoki
The septum transversum mesenchyme induces gall bladder development
title The septum transversum mesenchyme induces gall bladder development
title_full The septum transversum mesenchyme induces gall bladder development
title_fullStr The septum transversum mesenchyme induces gall bladder development
title_full_unstemmed The septum transversum mesenchyme induces gall bladder development
title_short The septum transversum mesenchyme induces gall bladder development
title_sort septum transversum mesenchyme induces gall bladder development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744069/
https://www.ncbi.nlm.nih.gov/pubmed/23951403
http://dx.doi.org/10.1242/bio.20135348
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