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Phosphoantigen/IL2 Expansion and Differentiation of Vγ2Vδ2 T Cells Increase Resistance to Tuberculosis in Nonhuman Primates

Dominant Vγ2Vδ2 T-cell subset exist only in primates, and recognize phosphoantigen from selected pathogens including M. tuberculosis(Mtb). In vivo function of Vγ2Vδ2 T cells in tuberculosis remains unknown. We conducted mechanistic studies to determine whether earlier expansion/differentiation of Vγ...

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Detalles Bibliográficos
Autores principales:	Chen, Crystal Y., Yao, Shuyu, Huang, Dan, Wei, Huiyong, Sicard, Helene, Zeng, Gucheng, Jomaa, Hassan, Larsen, Michelle H., Jacobs, William R., Wang, Richard, Letvin, Norman, Shen, Yun, Qiu, Liyou, Shen, Ling, Chen, Zheng W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744401/ https://www.ncbi.nlm.nih.gov/pubmed/23966854 http://dx.doi.org/10.1371/journal.ppat.1003501

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