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Endogenous Cholinergic Inputs and Local Circuit Mechanisms Govern the Phasic Mesolimbic Dopamine Response to Nicotine

Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal pathway of nicotine action: direct stimulation of the DAergic cells through n...

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Detalles Bibliográficos
Autores principales: Graupner, Michael, Maex, Reinoud, Gutkin, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744411/
https://www.ncbi.nlm.nih.gov/pubmed/23966848
http://dx.doi.org/10.1371/journal.pcbi.1003183