Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma

Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism. These changes represent multiple biochemical adaptations in glucose and fatty acid metabolism that supports malignant proliferation. However,...

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Detalles Bibliográficos
Autores principales: Yang, Youfeng, Lane, Andrew N., Ricketts, Christopher J., Sourbier, Carole, Wei, Ming-Hui, Shuch, Brian, Pike, Lisa, Wu, Min, Rouault, Tracey A., Boros, Laszlo G., Fan, Teresa W.-M., Linehan, W. Marston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744468/
https://www.ncbi.nlm.nih.gov/pubmed/23967283
http://dx.doi.org/10.1371/journal.pone.0072179

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