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Soluble Variants of Human Recombinant Glutaminyl Cyclase

Recombinant human Glutaminyl Cyclase expressed in E. coli is produced as inclusion bodies. Lack of glycosylation is the main origin of its accumulation in insoluble aggregates. Mutation of single isolated hydrophobic amino acids into negative amino acids was not able to circumvent inclusion bodies f...

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Detalles Bibliográficos
Autores principales:	Castaldo, Cristiana, Ciambellotti, Silvia, de Pablo-Latorre, Raquel, Lalli, Daniela, Porcari, Valentina, Turano, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744504/ https://www.ncbi.nlm.nih.gov/pubmed/23977104 http://dx.doi.org/10.1371/journal.pone.0071657

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