Cargando…

Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation

Abnormal TGF-β1/Smad3 activation plays an important role in the pathogenesis of pulmonary fibrosis, which can be prevented by paclitaxel (PTX). This study aimed to investigate an antifibrotic effect of the low-dose PTX (10 to 50 nM in vitro, and 0.6 mg/kg in vivo). PTX treatment resulted in phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Congjie, Song, Xiaodong, Li, Youjie, Han, Fang, Gao, Shuyan, Wang, Xiaozhi, Xie, Shuyang, Lv, Changjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744547/ https://www.ncbi.nlm.nih.gov/pubmed/23967091 http://dx.doi.org/10.1371/journal.pone.0070725

Ejemplares similares

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis
por: Tardif, Ginette, et al.
Publicado: (2013)

Engeletin ameliorates pulmonary fibrosis through endoplasmic reticulum stress depending on lnc949-mediated TGF-β1-Smad2/3 and JNK signalling pathways
por: Zhang, Jinjin, et al.
Publicado: (2020)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
por: Loboda, Agnieszka, et al.
Publicado: (2016)

Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-β Signaling
por: Li, Weihao, et al.
Publicado: (2019)

Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1/Smads Signaling Pathway
por: Chen, Hongshu, et al.
Publicado: (2017)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Astragaloside IV Synergizing with Ferulic Acid Ameliorates Pulmonary Fibrosis by TGF-β1/Smad3 Signaling
por: Tong, Jiahuan, et al.
Publicado: (2021)

Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway
por: Xu, Man, et al.
Publicado: (2021)

Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
por: Luong, Vu Huy, et al.
Publicado: (2018)

Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
por: Yang, Hun Yong, et al.
Publicado: (2019)

MicroRNA-140-5p Mediates Renal Fibrosis Through TGF-β1/Smad Signaling Pathway by Directly Targeting TGFBR1
por: Liao, Weitang, et al.
Publicado: (2020)

Metformin Ameliorates Chronic Colitis-Related Intestinal Fibrosis via Inhibiting TGF-β1/Smad3 Signaling
por: Wang, Ying, et al.
Publicado: (2022)

Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/β-catenin and TGF-β/smads pathways
por: Zaafan, Mai A., et al.
Publicado: (2021)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Tanshinone IIA regulates the TGF-β1/Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis
por: Xu, Lianjie, et al.
Publicado: (2022)

Huangqi Shengmai Yin Ameliorates Myocardial Fibrosis by Activating Sirtuin3 and Inhibiting TGF-β/Smad Pathway
por: Pan, Jianheng, et al.
Publicado: (2021)

Canagliflozin and irbesartan ameliorate renal fibrosis via the TGF-β1/Smad signaling pathway in Dahl salt-sensitive rats
por: Zhai, Jianlong, et al.
Publicado: (2023)

Amelioration of paraquat-induced pulmonary fibrosis in mice by regulating miR-140-5p expression with the fibrogenic inhibitor Xuebijing
por: Dong, Min-na, et al.
Publicado: (2020)

Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway
por: Li, Hongbo, et al.
Publicado: (2018)

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway
por: Jiang, Jintao, et al.
Publicado: (2020)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice
por: Huang, Chunling, et al.
Publicado: (2013)

Irbesartan ameliorates myocardial fibrosis in diabetic cardiomyopathy rats by inhibiting the TGFβ1/Smad2/3 pathway
por: Zong, Min, et al.
Publicado: (2020)

Piperine ameliorates the severity of fibrosis via inhibition of TGF-β/SMAD signaling in a mouse model of chronic pancreatitis
por: Choi, Ji-Won, et al.
Publicado: (2019)

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells
por: Hsu, Yu-An, et al.
Publicado: (2020)

Upregulation of miR-101a Suppresses Chronic Renal Fibrosis by Regulating KDM3A via Blockade of the YAP-TGF-β-Smad Signaling Pathway
por: Ding, Hong, et al.
Publicado: (2020)

Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFβ1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway
por: Shen, Ke, et al.
Publicado: (2021)

Sitagliptin ameliorates diabetic nephropathy by blocking TGF-β1/Smad signaling pathway
por: Wang, Dongdong, et al.
Publicado: (2018)

Calcium-sensing receptor promotes high glucose-induced myocardial fibrosis via upregulation of the TGF-β(1)/Smads pathway in cardiac fibroblasts
por: Yuan, Hui, et al.
Publicado: (2019)

Pirfenidone modulates macrophage polarization and ameliorates radiation‐induced lung fibrosis by inhibiting the TGF‐β1/Smad3 pathway
por: Ying, Hangjie, et al.
Publicado: (2021)

Polydatin ameliorates pulmonary fibrosis by suppressing inflammation and the epithelial mesenchymal transition via inhibiting the TGF-β/Smad signaling pathway
por: Qiu, Yue, et al.
Publicado: (2019)

The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway
por: Wan, Guoguo, et al.
Publicado: (2023)

Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway
por: Shan, Yangyang, et al.
Publicado: (2018)

NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats
por: Yang, Jiandong, et al.
Publicado: (2011)

Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192
por: Sun, Lin, et al.
Publicado: (2011)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
por: Stolfi, Carmine, et al.
Publicado: (2020)

miR-375 is upregulated in acquired paclitaxel resistance in cervical cancer
por: Shen, Y, et al.
Publicado: (2013)

A novel lnc-PCF promotes the proliferation of TGF-β1-activated epithelial cells by targeting miR-344a-5p to regulate map3k11 in pulmonary fibrosis
por: Liu, Huizhu, et al.
Publicado: (2017)

SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway
por: Guo, Yanhong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9jauiosf10hei83amcnc8p9m73