Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients. No...

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Detalles Bibliográficos
Autores principales: Dimicoli, Sophie, Wei, Yue, Bueso-Ramos, Carlos, Yang, Hui, DiNardo, Courtney, Jia, Yu, Zheng, Hong, Fang, Zhihong, Nguyen, Martin, Pierce, Sherry, Chen, Rui, Wang, Hui, Wu, Chenghua, Garcia-Manero, Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744562/
https://www.ncbi.nlm.nih.gov/pubmed/23976989
http://dx.doi.org/10.1371/journal.pone.0071120

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