Cargando…

The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean

Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Ju Seung, Ahn, Sung-Min, Jung, Young Kul, Kwon, Oh Sang, Kim, Yun Soo, Choi, Duck Joo, Kim, Ju Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744711/
https://www.ncbi.nlm.nih.gov/pubmed/23960450
http://dx.doi.org/10.3346/jkms.2013.28.8.1213
_version_ 1782280633063571456
author Kim, Ju Seung
Ahn, Sung-Min
Jung, Young Kul
Kwon, Oh Sang
Kim, Yun Soo
Choi, Duck Joo
Kim, Ju Hyun
author_facet Kim, Ju Seung
Ahn, Sung-Min
Jung, Young Kul
Kwon, Oh Sang
Kim, Yun Soo
Choi, Duck Joo
Kim, Ju Hyun
author_sort Kim, Ju Seung
collection PubMed
description Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P=0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P=0.282), and by 78% and 71% (P=0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR.
format Online
Article
Text
id pubmed-3744711
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-37447112013-08-19 The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean Kim, Ju Seung Ahn, Sung-Min Jung, Young Kul Kwon, Oh Sang Kim, Yun Soo Choi, Duck Joo Kim, Ju Hyun J Korean Med Sci Original Article Two variants of the inosine triphosphatase (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at rs7270101 all 133 were AA. The mean values of Hemoglobin (Hgb) after 4, 8, and 12 weeks of treatment in groups A and B were 12.2 and 14.0, 11.8 and 13.2, and 11.5 and 12.9, respectively (P=0.001, 0.036, 0.036). Sustained virologic response (SVR) was achieved in 67.8% (40/59) of genotype 1 patients and in 75% (27/36) of non-genotype 1 patients. Regarding ITPA variants, SVR was achieved by 66% and 80% of genotype 1 (P=0.282), and by 78% and 71% (P=0.726) of non-genotype 1. SVR was not significantly different in groups A and B. In conclusion, non-CC at rs1127354 without involvement of rs7270101 is strongly associated with protection from ribavirin-induced anemia, however, ITPA genotype is not associated with SVR. The Korean Academy of Medical Sciences 2013-08 2013-07-31 /pmc/articles/PMC3744711/ /pubmed/23960450 http://dx.doi.org/10.3346/jkms.2013.28.8.1213 Text en © 2013 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Ju Seung
Ahn, Sung-Min
Jung, Young Kul
Kwon, Oh Sang
Kim, Yun Soo
Choi, Duck Joo
Kim, Ju Hyun
The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title_full The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title_fullStr The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title_full_unstemmed The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title_short The Impact of Inosine Triphosphatase Variants on Hemoglobin Level and Sustained Virologic Response of Chronic Hepatitis C in Korean
title_sort impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis c in korean
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744711/
https://www.ncbi.nlm.nih.gov/pubmed/23960450
http://dx.doi.org/10.3346/jkms.2013.28.8.1213
work_keys_str_mv AT kimjuseung theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT ahnsungmin theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT jungyoungkul theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kwonohsang theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kimyunsoo theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT choiduckjoo theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kimjuhyun theimpactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kimjuseung impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT ahnsungmin impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT jungyoungkul impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kwonohsang impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kimyunsoo impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT choiduckjoo impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean
AT kimjuhyun impactofinosinetriphosphatasevariantsonhemoglobinlevelandsustainedvirologicresponseofchronichepatitiscinkorean