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Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation()
Accurate unbound solution 3D-structures of ligands provide unique opportunities for medicinal chemistry and, in particular, a context to understand binding thermodynamics and kinetics. Previous methods of deriving these 3D-structures have had neither the accuracy nor resolution needed for drug desig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744816/ https://www.ncbi.nlm.nih.gov/pubmed/23886813 http://dx.doi.org/10.1016/j.bmc.2013.06.056 |