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Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

Hexokinase II (HK-II) is an enzyme that catalyzes the first step in glycolysis and localizes not only in the cytosol but also at mitochondria. Akt, activated by insulin-like growth factor 1 (IGF-1) treatment in neonatal rat ventricular myocytes, translocates to mitochondria and increases mitochondri...

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Detalles Bibliográficos
Autores principales:	Roberts, David J., Tan-Sah, Valerie P., Smith, Jeffery M., Miyamoto, Shigeki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745326/ https://www.ncbi.nlm.nih.gov/pubmed/23836898 http://dx.doi.org/10.1074/jbc.M113.482026

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