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Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

Autophagy is an evolutionarily conserved lysosomal degradation pathway, yet the underlying mechanisms remain poorly understood. Nicotinic acid adenine dinucleotide phosphate (NAADP), one of the most potent Ca(2+) mobilizing messengers, elicits Ca(2+) release from lysosomes via the two pore channel 2...

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Detalles Bibliográficos
Autores principales:	Lu, Yingying, Hao, Bai-Xia, Graeff, Richard, Wong, Connie W. M., Wu, Wu-Tian, Yue, Jianbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745369/ https://www.ncbi.nlm.nih.gov/pubmed/23836916 http://dx.doi.org/10.1074/jbc.M113.484253

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