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HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women
As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745383/ https://www.ncbi.nlm.nih.gov/pubmed/23976978 http://dx.doi.org/10.1371/journal.pone.0071040 |
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author | Li, Dalin Fu, Zhenkun Chen, Shuang Yuan, Weiguang Liu, Yanhong Li, Liqun Pang, Da Li, Dianjun |
author_facet | Li, Dalin Fu, Zhenkun Chen, Shuang Yuan, Weiguang Liu, Yanhong Li, Liqun Pang, Da Li, Dianjun |
author_sort | Li, Dalin |
collection | PubMed |
description | As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P<0.05). One haplotype (CTGCGG) that was associated with breast cancer was found via haplotype analysis. Our research also indicated an association between polymorphisms of HVEM and clinicopathologic features, including lymph node metastasis, estrogen receptor, progesterone receptor and P53. Our results primarily indicate that polymorphisms of the HVEM gene were associated with the risk of sporadic breast cancer in northeast Chinese females. |
format | Online Article Text |
id | pubmed-3745383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37453832013-08-23 HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women Li, Dalin Fu, Zhenkun Chen, Shuang Yuan, Weiguang Liu, Yanhong Li, Liqun Pang, Da Li, Dianjun PLoS One Research Article As a costimulatory molecule, Herpesvirus entry mediator (HVEM) can bind with several costimulatory members, thus HVEM plays different roles in T cell immunity. HVEM and its ligands have been involved in the pathogenesis of various autoimmune, inflammatory diseases and tumors. In the current study, we conducted a case-control study comparing polymorphisms of HVEM and breast cancer. Subjects included 575 females with breast cancer and 604 age-matched healthy controls. Six HVEM SNPs (rs2281852, rs1886730, rs2234163, rs11573979, rs2234165, and rs2234167) were genotyped by PCR-RFLP. The results showed significant differences in genotypes and alleles between rs1886730 and rs2234167 (P<0.05). One haplotype (CTGCGG) that was associated with breast cancer was found via haplotype analysis. Our research also indicated an association between polymorphisms of HVEM and clinicopathologic features, including lymph node metastasis, estrogen receptor, progesterone receptor and P53. Our results primarily indicate that polymorphisms of the HVEM gene were associated with the risk of sporadic breast cancer in northeast Chinese females. Public Library of Science 2013-08-16 /pmc/articles/PMC3745383/ /pubmed/23976978 http://dx.doi.org/10.1371/journal.pone.0071040 Text en © 2013 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Li, Dalin Fu, Zhenkun Chen, Shuang Yuan, Weiguang Liu, Yanhong Li, Liqun Pang, Da Li, Dianjun HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title | HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title_full | HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title_fullStr | HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title_full_unstemmed | HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title_short | HVEM Gene Polymorphisms Are Associated with Sporadic Breast Cancer in Chinese Women |
title_sort | hvem gene polymorphisms are associated with sporadic breast cancer in chinese women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745383/ https://www.ncbi.nlm.nih.gov/pubmed/23976978 http://dx.doi.org/10.1371/journal.pone.0071040 |
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